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Granzyme K+ CD8 T cells in autoimmunity.
1Division of Rheumatology, Department of Medicine, University of Colorado Anschutz Medical Center, Aurora, CO, USA.
Best Practice & Research. Clinical Rheumatology
|February 2, 2024
Summary
CD8 T cells expressing granzyme K are found in rheumatoid arthritis and other autoimmune diseases. Their specific roles in disease development are currently being investigated.
Area of Science:
- Immunology
- Autoimmunity
Background:
- CD8 T cells expressing granzyme K are present in rheumatoid arthritis synovial tissue.
- These cells are also found in other autoimmune disease tissues.
- The function of these cells in autoimmune pathogenesis is under investigation.
Purpose of the Study:
- To review the evidence for granzyme K-expressing CD8 T cells in autoimmune disease tissues.
- To discuss the potential roles of these cells in the pathogenesis of autoimmune conditions.
Main Methods:
- Literature review of studies on CD8 T cells and granzyme K in autoimmune diseases.
Main Results:
- Granzyme K-expressing CD8 T cells are enriched at sites of autoimmune disease.
- Evidence suggests these cells may play a role in disease pathogenesis.
Conclusions:
- Further research is needed to fully understand the functional significance of granzyme K-expressing CD8 T cells in autoimmune diseases.
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