Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Renal Drug Clearance: Comparison Between Renal Excretion Methods01:08

Renal Drug Clearance: Comparison Between Renal Excretion Methods

840
Renal clearance is a critical parameter encompassing kidney filtration, secretion, and reabsorption processes. It is calculated using a specific equation to determine the rate at which the kidneys clear a drug.
Renal clearance is often associated with the renal glomerular filtration rate (GFR), which represents the rate at which plasma is filtered through the glomeruli in the kidney. When drug reabsorption is minimal and there is no active secretion, renal clearance is closely related to the...
840
Determination of Renal Drug Clearance: Graphical and Midpoint Methods01:07

Determination of Renal Drug Clearance: Graphical and Midpoint Methods

497
Renal clearance, a crucial parameter in pharmacokinetics, can be determined using two different methods: the graphical method and the midpoint method. These methods provide insights into the rate of drug excretion by the kidneys and aid in assessing renal function.
The graphical method involves plotting the rate of drug excretion in urine against the plasma drug concentration. By analyzing the graph, the clearance can be calculated and obtained. Drugs rapidly excreted by the kidneys exhibit a...
497
Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate01:25

Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate

143
The glomerular filtration rate (GFR) is a critical indicator of kidney health, reflecting how well the kidneys filter blood. Changes in GFR can signal potential kidney impairment, necessitating accurate measurement methods to monitor kidney function effectively.Various molecules can serve as markers for GFR measurement, with the ideal marker meeting several specific criteria. It must freely filter at the glomerulus, avoid reabsorption or secretion by the renal tubules, remain unmetabolized, not...
143
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

337
Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
337
Physiology of the Genitourinary System I: Renal Blood Flow and Glomerular Filtration01:29

Physiology of the Genitourinary System I: Renal Blood Flow and Glomerular Filtration

1.9K
The kidneys are vital organs responsible for regulating blood filtration, waste excretion, and fluid balance, all of which are crucial for maintaining homeostasis. Renal physiology examines renal blood flow, glomerular filtration, and urine formation, ensuring the body’s internal environment remains stable.Renal Blood FlowThe kidneys receive about 20-25% of the cardiac output, typically around 1200 mL of blood per minute in an average adult. Blood flows into the kidneys through the renal...
1.9K
Diabetic Nephropathy01:28

Diabetic Nephropathy

32
Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration...
32

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluating and Mitigating Carbon Dioxide Equivalent Emissions in Stroke Management: A Modeling Study.

Journal of the American Heart Association·2026
Same author

The role of platelet-derived growth factor in uremic vascular calcification.

Kidney international·2026
Same author

Strategic timing of contralateral nephrectomy after ischemic acute kidney injury prevents chronic kidney disease by enhancing progenitor proliferation, attenuating polyploidization and reshaping the immune response.

Kidney international·2026
Same author

Infrastructure and policy reforms to facilitate collaboration in medical research.

Nature reviews. Nephrology·2026
Same author

CCR5 and CD74 are potential therapeutic targets for necroinflammation in preclinical cholesterol crystal embolism.

Science translational medicine·2026
Same author

The evolving field of nephrology: what comes next? A report from the European Renal Association Scientific Advisory Board.

Clinical kidney journal·2026
Same journal

Pathodashboard: an epidemiological atlas for tumour diagnostics.

Pathologie (Heidelberg, Germany)·2026
Same journal

Pathologie (Heidelberg, Germany)·2026
Same journal

Pathologie (Heidelberg, Germany)·2026
Same journal

[Genetic diagnostics].

Pathologie (Heidelberg, Germany)·2026
Same journal

[Guideline development for MRD diagnostics in AML as a blueprint for solid tumors].

Pathologie (Heidelberg, Germany)·2026
Same journal

[Therapy of melanoma : Current standards and future perspectives].

Pathologie (Heidelberg, Germany)·2026
See all related articles

Related Experiment Video

Updated: May 3, 2026

Supervised Machine Learning for Semi-Quantification of Extracellular DNA in Glomerulonephritis
09:16

Supervised Machine Learning for Semi-Quantification of Extracellular DNA in Glomerulonephritis

Published on: June 18, 2020

6.9K

[Advances in computational quantitative nephropathology].

Roman D Bülow1, Patrick Droste1,2, Peter Boor3,4

  • 1Institut für Pathologie, Sektion Nephropathologie, Universitätsklinikum RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Deutschland.

Pathologie (Heidelberg, Germany)
|February 2, 2024
PubMed
Summary
This summary is machine-generated.

Renal pathomics, using quantitative histology data from next-generation morphometry (NGM), shows clinical utility for prognosis. Further standardization and prospective studies are needed for NGM development in nephropathology.

Keywords:
KidneyNeural networks, computerPrognosisProspective studiesReferences standards

More Related Videos

Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes
11:47

Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes

Published on: March 4, 2022

2.3K
5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

583

Related Experiment Videos

Last Updated: May 3, 2026

Supervised Machine Learning for Semi-Quantification of Extracellular DNA in Glomerulonephritis
09:16

Supervised Machine Learning for Semi-Quantification of Extracellular DNA in Glomerulonephritis

Published on: June 18, 2020

6.9K
Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes
11:47

Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes

Published on: March 4, 2022

2.3K
5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

583

Area of Science:

  • Computational pathology
  • Nephropathology
  • Digital pathology

Context:

  • Semiquantitative histological scoring is standard in nephropathology.
  • Computational nephropathology focuses on quantitative histology data, termed pathomics.
  • Next-generation morphometry (NGM) uses artificial neural networks for segmentation and data generation.

Purpose:

  • To review current renal pathomics studies.
  • To identify challenges and solutions in the field.

Summary:

  • Recent studies utilize NGM for renal pathomics, generating quantitative data from histology.
  • These morphometric data have demonstrated clinical utility, particularly for prognosis assessment.
  • Key challenges include standardization and the need for prospective evidence.

Impact:

  • Renal pathomics offers valuable clinical and translational insights.
  • Advancements in NGM can enhance diagnostic accuracy and prognostic capabilities in nephrology.
  • Standardization and prospective validation are crucial for widespread adoption.