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Related Experiment Video

Updated: Jul 4, 2025

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
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The association between post-traumatic stress disorder (PTSD) and executive functioning.

Nawal Ouhmad1, Nicolas Combalbert1, Wissam El Hage2

  • 1EA 2114, laboratoire PAVeA, Université de Tours, Tours, France.

Cognitive Neuropsychiatry
|February 3, 2024
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Summary

This study found that Post-Traumatic Stress Disorder (PTSD) is linked to executive function deficits. Depression significantly contributes to these executive function disturbances in individuals with PTSD.

Keywords:
Post-traumatic stress disorderanxietydepressiondissociationexecutive functions

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Psychology

Background:

  • Post-Traumatic Stress Disorder (PTSD) is associated with executive functioning impairments.
  • Understanding the interplay between PTSD, executive functions, anxiety, and depression is crucial for clinical populations.

Purpose of the Study:

  • To investigate the relationship between executive functions and the presence of anxiety and depression in individuals with PTSD.
  • To determine if executive function disturbances in PTSD are primarily linked to PTSD severity or comorbid depression.

Main Methods:

  • A sample of 180 participants was divided into three groups: PTSD (n=60), trauma-exposed without PTSD (n=60), and controls (n=60).
  • Participants were assessed for PTSD, dissociation, executive functions, anxiety, and depression.

Main Results:

  • Individuals with PTSD exhibited significant difficulties in executive functioning.
  • These executive function deficits were found to be related to the levels of anxiety and depression experienced by the participants.
  • Specifically, working memory updating issues were strongly associated with depression levels.

Conclusions:

  • PTSD severity correlates positively with executive function disturbances.
  • Depression appears to be a primary driver of executive function disturbances, particularly in working memory, in individuals with PTSD, more so than PTSD alone.