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Updated: Jul 4, 2025
04:29
Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
Published on: January 7, 2019
28.6K
Novel rapid treatment options for adolescent depression
Sandra Ledesma-Corvi1, Jordi Jornet-Plaza1, Laura Gálvez-Melero1
1Neuropharmacology Research Group, IUNICS, University of the Balearic Islands, Palma, Spain; Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain.
Pharmacological Research
|February 3, 2024
Summary
Novel fast-acting antidepressants are needed for adolescent depression. This review explores non-pharmacological and pharmacological options like brain stimulation, ketamine, psychedelics, and cannabidiol for rapid treatment.
Area of Science:
- Neuroscience
- Psychiatry
- Pharmacology
Background:
- Adolescent depression requires faster-acting treatments than current selective serotonin reuptake inhibitors.
- Existing antidepressants have a slow onset of action, leaving a critical treatment gap.
Approach:
- Reviews preclinical and clinical evidence for novel antidepressant strategies in adolescents.
- Examines neuromodulators (e.g., brain stimulation) and pharmacological agents (e.g., ketamine, psychedelics, cannabidiol).
Key Points:
- Investigates fast-acting antidepressants for treatment-resistant adolescent depression and suicidal risk.
- Considers potential sex-, age-, and dose-related differences for efficacy and safety.
- Highlights the need for further preclinical and clinical research.
Conclusions:
- Novel non-pharmacological and pharmacological approaches show promise for rapid antidepressant effects in adolescents.
- Further research is crucial to develop safe and effective fast-acting treatments for adolescent depression.
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