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Pharmacological interventions in human aging.

Michael Angelo Petr¹, Frida Matiyevskaya¹, Brenna Osborne¹

¹Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen 2200, Denmark.

Ageing Research Reviews

|February 3, 2024

Summary

This summary is machine-generated.

This review summarizes 136 clinical trials targeting age-related diseases with pharmacological interventions. A new database, AgingDB, centralizes information on these trials and their outcomes for easier access.

Keywords:

Age-associated diseases Aging Clinical trials Database Pharmacological interventions Small molecules

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Area of Science:

Gerontology and Pharmacology
Clinical Trial Analysis

Background:

Age-related diseases pose a significant health challenge.
Pharmacological interventions are a key area of research for mitigating aging.
Information on clinical trials for aging is currently fragmented.

Purpose of the Study:

To consolidate and review existing clinical trials focused on pharmacological interventions for aging.
To create a centralized, searchable database (AgingDB) of these trials.
To provide an overview of current pharmacological strategies targeting human aging.

Main Methods:

Systematic review of 136 completed or ongoing clinical trials.
Development of a comprehensive database (AgingDB) detailing trial information and outcomes.
Data compilation and analysis of pharmacological interventions in aging research.

Main Results:

Summarized data from 136 clinical trials related to aging and pharmacology.
Established AgingDB (www.agingdb.com) as a resource for tracking trials.
Identified current pharmacological strategies applied to target human aging.

Conclusions:

Pharmacological interventions show promise for alleviating age-related diseases.
The AgingDB database offers a valuable, centralized resource for researchers and interested individuals.
This work provides a comprehensive overview of the pharmacological landscape in aging research.