Related Experiment Video
Updated: Jun 13, 2026
10:25
Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection
Published on: June 5, 2021
4.7K
Assessment of the predictive value of plasma calprotectin in the evolution of SARS-Cov-2 primo-infection
Gauthier Lignier1, Caroline Camaré2, Thibaut Jamme3
1Faculty of Pharmacy, Toulouse III university, France; Medical biochemistry laboratory, CHU Toulouse, France.
Infectious Diseases Now
|February 3, 2024
Summary
Early plasma calprotectin levels can indicate COVID-19 severity but aren't superior to existing markers. Further research is needed for high-risk patients and serial measurements.
Area of Science:
- Infectious Diseases
- Biomarkers
- Critical Care Medicine
Background:
- The COVID-19 pandemic necessitates proactive strategies to prevent critical care overload.
- Assessing easily accessible biomarkers is crucial for predicting disease progression.
Purpose of the Study:
- To evaluate the predictive value of early plasma calprotectin concentration for adverse outcomes in primary SARS-CoV-2 infection.
- To determine if calprotectin levels correlate with COVID-19 severity and cytokine storm activity.
Main Methods:
- A cohort of 308 patients with PCR-confirmed SARS-CoV-2 infection was studied.
- Plasma calprotectin levels were measured within 24 hours of hospitalization.
- Patient data, including medical records and severity classifications, were collected.
Main Results:
- Early plasma calprotectin concentration was significantly associated with progression to severe COVID-19 (RR: 2.2 [1.6-2.7]).
- Multivariate analysis indicated calprotectin did not provide additional predictive information beyond established parameters like age, GFR, and CRP.
Conclusions:
- An early single calprotectin blood test may aid in predicting COVID-19 progression but is not superior to current markers.
- Calprotectin's utility for high-risk patients (e.g., immunocompromised) warrants further investigation.
- The value of serial calprotectin measurements for monitoring COVID-19 severity requires additional study.
