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Effect of ketogenic diet on blood pressure: A GRADE-Assessed systematic review and meta-analysis of randomized
Mohammad Reza Amini1, Moein Askarpour2, Hamid Ghalandari3
1Student Research Committee, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition & Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Insights
Ketogenic diets (KDs) show no significant impact on reducing blood pressure (BP) in individuals with hypertension. Further research is needed to determine optimal fat intake for potential benefits.
Area of Science:
- Cardiology
- Nutrition Science
- Metabolic Health
Background:
- Cardiovascular diseases (CVDs) are a leading global cause of mortality.
- Hypertension is a major risk factor for CVDs.
- Ketogenic diets (KDs) are increasingly studied for potential health benefits.
Conclusions:
- Current evidence suggests ketogenic diets are not effective in improving blood pressure.
- Further research is recommended to explore the optimal fat intake proportion for potential clinical benefits of KDs on BP.
- The role of KDs in hypertension management requires additional investigation.
Aims:
Cardiovascular diseases (CVDs) are major causes of mortality around the world. High blood pressure (BP) or hypertension is one of the most significant predisposing factors to CVDs. Ketogenic diets (KDs) have been the center of attention for their possible health benefits. The aim of this analysis is to study the impact of KDs on BP through the existing literature.
Data Synthesis:
We investigated the impact of KDs on systolic and diastolic blood pressures (SBP and DBP) conducted in the format of randomized controlled trials (RCTs). Four online databases (PubMed/Medline, SCOPUS, Cochrane Library, and Google Scholar) were searched from inception up to November 2022. Subgroup analyses were carried out to find the sources of heterogeneities. Twenty-three RCTs with 1664 participants were identified. KDs did not exert any significant impacts on SBP (WMD: -0.87 mmHg, 95% CI: -2.05, 0.31) nor DBP (WMD: -0.11 mmHg, 95% CI -1.14, 0.93). Subgroup analyses did not reveal any further information. Also, non-linear dose-response analysis could not detect any associations between the percentage of calorie intake from fat in the KD format and BP levels.
Conclusion:
KDs do not seem to be effective in improving BP. Nonetheless, further investigations are recommended to examine the proportion of fat intake needed to induce favorable clinical impacts.
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