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Chemically-blocked Antibody Microarray for Multiplexed High-throughput Profiling of Specific Protein Glycosylation in Complex Samples
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Combination of serum alpha-fetoprotein, PIVKA-Ⅱ and glypican-3 in diagnosis of hepatocellular carcinoma: a

Hongliang Song1,2, Jianguo Wang3,4, Hui Zhang3,4

  • 1The Fourth Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou 310053, China. shl2399@163.com.

Zhejiang Da Xue Xue Bao. Yi Xue Ban = Journal of Zhejiang University. Medical Sciences
|February 3, 2024
PubMed
Summary
This summary is machine-generated.

Protein induced by vitamin K absence or antagonist-II (PIVKA-II) shows high diagnostic value for hepatocellular carcinoma (HCC) alone. Combining alpha-fetoprotein (AFP) with PIVKA-II improves diagnostic sensitivity for HCC.

Keywords:
Alpha-fetoproteinDiagnosisGlypican-3Hepatocellular carcinomaMeta-analysisProtein induced by vitamin K absence or antagonist-ⅡSerum markers

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Area of Science:

  • Hepatocellular Carcinoma (HCC) Diagnostics
  • Biomarker Discovery
  • Oncology Research

Background:

  • Hepatocellular carcinoma (HCC) is a major global health concern.
  • Accurate early diagnosis of HCC is crucial for effective treatment and improved patient outcomes.
  • Serum biomarkers play a vital role in non-invasive HCC detection.

Conclusions:

  • PIVKA-II is a valuable single serum marker for HCC diagnosis.
  • Combining two markers, specifically AFP with PIVKA-II, significantly enhances diagnostic sensitivity for HCC.
  • Combining all three markers (AFP, PIVKA-II, GPC-3) did not further improve diagnostic performance.