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  11. Apob Is A Potential Prognostic Biomarker In Hepatocellular Carcinoma

APOB is a potential prognostic biomarker in hepatocellular carcinoma

Zhifeng Lin1, Xiaohui Ji2, Nana Tian3

  • 1Department of Medical Record; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; Guangdong Provincial Key Laboratory of Major Obstetric Diseases, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. Linzhifeng@gzhmu.edu.cn.

Discover Oncology
|February 3, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Apolipoprotein B (APOB) expression is decreased in hepatocellular carcinoma (HCC). Lower APOB levels correlate with immune infiltration and predict poor prognosis in HCC patients, highlighting its potential as a therapeutic target.

Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • Hepatocellular carcinoma (HCC) presents poor prognostic outcomes.
  • Apolipoprotein B (APOB) influences tumor development, but its role in HCC is unclear.

Purpose of the Study:

  • To investigate the expression, biological function, and prognostic significance of APOB in HCC.
  • To explore APOB's relationship with clinicopathological features, immune infiltration, and regulatory ncRNAs in HCC.

Main Methods:

  • Analysis of APOB expression using TIMER2.0, UALCAN, and Human Protein Atlas databases.
  • Enrichment analysis (LinkedOmics), correlation analysis (TISIDB, GEPIA, TIMER2.0), and survival analysis (Kaplan-Meier plotter, Cox regression).
  • Identification of potential regulatory ncRNAs using StarBase and GEPIA.
Keywords:
APOBExpressionHepatocellular carcinomaNcRNAs

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Main Results:

  • APOB expression is significantly decreased in HCC tissues.
  • Decreased APOB correlates with immune cell infiltration and immune checkpoint genes.
  • Lower APOB expression is associated with adverse clinicopathological features and predicts poor overall survival (OS), recurrence-free survival (RFS), disease-specific survival (DSS), and progression-free survival (PFS).
  • Six potential non-coding RNA (ncRNA) pathways associated with APOB in HCC were identified.

Conclusions:

  • Reduced APOB expression is a significant indicator of poor prognosis in HCC.
  • APOB's involvement in HCC pathogenesis and its potential as a biomarker warrant further investigation.
  • Understanding APOB's regulatory mechanisms, including ncRNA interactions, may offer therapeutic strategies for HCC.
Prognosis