Shock index creatinine: a new predictor of mortality in acute coronary syndrome patients

Area of Science:

• Cardiology
• Critical Care Medicine
• Medical Diagnostics

Background:

• The Shock Index Creatinine (SIC) score is a novel tool for patient risk stratification.
• While used in ST-Elevation Myocardial Infarction (STEMI), its utility in Acute Coronary Syndrome (ACS) requires further evaluation.
• Predicting in-hospital mortality in ACS patients is crucial for timely intervention.

Purpose of the Study:

• To evaluate the utility of the SIC score in predicting in-hospital mortality among ACS patients.
• To update the current SIC score for improved risk stratification in ACS.
• To assess the SIC score's performance across the entire spectrum of ACS.

Main Methods:

• A retrospective, single-centered cohort study included 1349 adult ACS patients.
• Data were collected between January 2018 and January 2022.
• In-hospital mortality was analyzed using binary logistic regression and ROC curve analysis.

Main Results:

• Multivariate analysis confirmed a significant association between SIC score and in-hospital mortality (p < 0.001).
• A high SIC score (≥25) was linked to a 2.655-fold increased odds of in-hospital mortality.
• The SIC score demonstrated acceptable predictive value (AUC = 0.789) with optimal sensitivity (71.5%) and specificity (74.4%) at a cutoff of ≥25.

Conclusions:

• The SIC score is a valuable tool for predicting in-hospital mortality in patients across all ACS spectrums.
• A SIC score of 25 or higher is particularly indicative of increased mortality risk.
• This study is the first to comprehensively evaluate the SIC score in the full range of ACS patients.