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Effect of cognitive-behavior therapy for children with functional abdominal pain: a meta-analysis
Xiaolan Huang1, Nan Jia1, Yan Zhang2
1Experiment center, Capital Institute of Pediatrics, Beijing, China.
Insights
Cognitive-Behavior Therapy (CBT) significantly reduces functional disability and pain intensity in children with functional abdominal pain (FAP). This therapy also improves quality of life, offering a valuable non-pharmacological treatment option.
Area of Science:
- Pediatric gastroenterology
- Clinical psychology
- Evidence-based medicine
Background:
- Functional abdominal pain (FAP) is a common condition in children.
- Cognitive-Behavior Therapy (CBT) is a validated non-pharmacological treatment for chronic pain.
- Previous studies suggested CBT's comparable efficacy to usual care for pediatric FAP.
Approach:
- Systematic review and meta-analysis of randomized controlled trials (RCTs) up to October 2022.
- Included various CBT delivery methods (in-person, web-based, phone-based).
- Synthesized results using weighted and standardized mean differences with 95% confidence intervals.
Key Points:
- CBT significantly reduced functional disability (SMD=-2.282) and pain intensity (SMD=-0.594) in children with FAP.
- CBT led to significant improvements in quality of life (SMD=14.097).
- No significant differences were found in depression, anxiety, or gastrointestinal symptoms compared to usual care.
Conclusions:
- CBT demonstrates significant benefits in reducing functional disability and pain intensity in pediatric FAP.
- The findings support CBT as a promising therapeutic approach for children with FAP.
- Further research is warranted to explore CBT's full potential in managing pediatric functional abdominal pain.
Background:
Cognitive-Behavior Therapy (CBT) is the validated non-pharmacological treatment for chronic pain in pediatric patients. While some suggested CBT were comparable to the usual care in reducing children's functional abdominal pain. This meta-analysis was designed to systematically review the literature for RCTs that investigated the efficacy of CBT in children with functional abdominal pain (FAP).
Methods:
PubMed, Embase, and the Cochrane library were searched for papers published up to October 2022. Studies applying different CBT delivery methods (in-person, web-based, phone-based) were included in this meta-analysis to evaluate the comprehensive effectiveness of CBT compared with usual care. Weighted and standardized mean difference with the 95% confidence intervals were used for the synthesis of the results. Primary outcome was the decrease of functional disability inventory (FDI) and the secondary outcomes were the decrease of severity in pain intensity, depression, anxiety, gastrointestinal symptoms, and improvement in physical quality of life (QoL).
Results:
A total of 10 RCTs with 1187 children were included in the final analysis. The results showed that CBT resulted in better effect in reducing functional disability inventory (SMD=-2.282, 95%CI: -4.537 to -0.027, P = 0.047), pain intensity (SMD=-0.594, 95%CI: -1.147 to -0.040, P = 0.036), and improving QoL (SMD = 14.097, 95%CI: 0.901 to 27.292, P = 0.036) compared with the control groups. Comparable effects were observed in the severity of depression (SMD=-0.493, 95%CI: -1.594 to 0.608, P = 0.380), anxiety (SMD=-0.062, 95%CI: -0.640 to 0.517, P = 0.835), and gastrointestinal symptoms (SMD=-1.096 95%CI: -2.243 to 0.050, P = 0.061) between CBT and usual treatment.
Conclusions:
We observed the differences in post-treatment FAP and pain intensity for children receiving CBT compared with children receiving treatment as usual. CBT in the setting of FAP demonstrates promising developments and highlights the need for future research.
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