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Abnormal Proliferation02:23

Abnormal Proliferation

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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  9. Predictive And Prognostic Markers
  11. Increased Acsl6 Expression Predicts A Favorable Prognosis In Triple-negative Breast Cancer

Increased ACSL6 Expression Predicts a Favorable Prognosis in Triple-negative Breast Cancer

Hui Hua1, Shuaikang Pan1, Haizhou Diao1

  • 1Department of Medical Oncology, The First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, China.

Current Medicinal Chemistry
|February 4, 2024

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Three Dimensional Cultures: A Tool To Study Normal Acinar Architecture vs. Malignant Transformation Of Breast Cells
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View abstract on PubMed

Summary
This summary is machine-generated.

Long-chain acyl-coenzyme A synthase 6 (ACSL6) is elevated in triple-negative breast cancer (TNBC). High ACSL6 expression correlates with better survival and increased immune cell infiltration, suggesting its potential as a prognostic marker.

Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • Long-chain acyl-coenzyme A synthases (ACSLs) are crucial for fatty acid metabolism.
  • ACSL dysregulation is implicated in cancer development.
  • The role of ACSL6 in triple-negative breast cancer (TNBC) remains uncharacterized.

Purpose of the Study:

  • To investigate the expression and function of ACSL6 in TNBC.
  • To evaluate ACSL6 as a potential diagnostic and prognostic biomarker for TNBC.

Main Methods:

  • Immunohistochemistry on TNBC tissue microarrays.
  • Analysis of ACSL6 mRNA levels using GTEx and TCGA databases.
  • Correlation analysis with clinical characteristics, survival data, and immune infiltration using bioinformatics tools (Kaplan-Meier Plotter, ESTIMATE, CIBERSORT, TISIDB).
Keywords:
ACSL6fatty acid metabolismimmune infiltrationprognostic biomarker.

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  • Assessment of drug sensitivity using the GDSC database.

    • Main Results:

    • ACSL6 expression is significantly upregulated in TNBC tissues compared to normal adjacent tissues.
    • High ACSL6 expression is associated with favorable survival outcomes in TNBC patients.
    • ACSL6 expression correlates positively with memory CD4 T cell infiltration and negatively with M2 macrophages and resting dendritic cells.
    • Elevated ACSL6 levels predict improved survival in patients receiving immunotherapy.

    Conclusions:

    • ACSL6 serves as a potential diagnostic and prognostic marker in TNBC.
    • ACSL6 expression is linked to immune responses within the tumor microenvironment.
    • Targeting ACSL6 may offer therapeutic benefits for TNBC patients, particularly those undergoing immunotherapy.
    triple-negative breast cancer