Related Experiment Video

Updated: Jul 4, 2025

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells
11:08

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells

Published on: February 14, 2025

778

MNK: A Novel Promising Target for Cancer Immunotherapy

Pei Shu1,2, Yanna Lei3, Ge Gao2

  • 1Division of Thoracic Tumor Multimodality Treatment, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.

Current Medicinal Chemistry
|February 4, 2024
PubMed

Insights

Mitogen-activated protein kinase-interacting kinases (MNKs) show promise as a new target for cancer immunotherapy. Understanding MNK function could expand treatment options for more cancer patients.

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • Cancer immunotherapy, particularly targeting immune checkpoints, has shown success in advanced cancers.
  • Limited response rates hinder broader application of current immunotherapies.
  • Novel therapeutic targets are needed to improve patient outcomes.

Purpose of the Study:

  • To review the structure, function, and expression of mitogen-activated protein kinase-interacting kinases (MNKs).
  • To elucidate the role of MNKs in tumor progression and cancer biology.
  • To evaluate MNKs as a potential novel target for cancer immunotherapy.

Main Methods:

  • Literature review of existing studies on MNKs in cancer.
  • Analysis of MNK structure, function, and expression patterns.
  • Examination of MNK involvement in cancer development and progression.

Main Results:

  • MNKs play a significant role in cancer biology and therapy.
  • Evidence suggests MNKs are closely correlated with cancer progression.
  • MNKs represent a promising new therapeutic target.

Conclusions:

  • A comprehensive understanding of MNKs is crucial for developing new cancer treatments.
  • Targeting MNKs may offer a novel strategy to enhance cancer immunotherapy.
  • Further research into MNKs could expand immunotherapy benefits to more patients.
Keywords:
MAPKMNKcancer therapyimmunotherapy.novel targetpromising target

More Related Videos

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases09:48

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases

Published on: August 23, 2024

371
Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer06:51

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Published on: July 21, 2018

17.9K

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.6K
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
526
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.5K
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
5.5K
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
163