Related Experiment Video
Updated: Jul 4, 2025
Intracoronary Acetylcholine Provocation Testing for Assessment of Coronary Vasomotor Disorders
Published on: August 18, 2016
Cardiac Mass and Cerebrovascular Accident as Primary Manifestations of Churg-Strauss Syndrome
Fariba Abbasi1,2, Ata Abbasi2, Alireza Rostamzadeh3
1Solid Tumor Research Center, Cellular and Molecular Medicine Research Institute, Urmia University of Medical Sciences, Urmia, Iran.
Insights
Eosinophilic granulomatosis with polyangiitis (EGPA), formerly Churg-Strauss syndrome, can manifest as a cardiac mass. This case highlights a large left ventricular granuloma in an EGPA patient, emphasizing the need for cardiac screening.
Area of Science:
- Cardiology
- Rheumatology
- Pathology
Background:
- Churg-Strauss syndrome (CSS), now eosinophilic granulomatosis with polyangiitis (EGPA), is a rare systemic vasculitis.
- EGPA is characterized by asthma, eosinophilia, and extravascular granulomas.
- Cardiac involvement in EGPA is linked to a poor prognosis.
Purpose of the Study:
- To report a case of a large left ventricular granuloma in a patient diagnosed with EGPA.
- To highlight the diagnostic approach and confirmation of EGPA in this patient.
- To emphasize the importance of cardiac evaluation in EGPA.
Main Methods:
- Echocardiography was used to detect a ventricular mass.
- Histopathologic evaluation confirmed the granuloma.
- Paraclinical findings aided in EGPA diagnosis.
Main Results:
- A large left ventricular granuloma was identified in a 45-year-old asthmatic male.
- Histopathology confirmed the granuloma and EGPA diagnosis.
- The patient presented with a cerebrovascular accident.
Conclusions:
- Cardiac involvement, such as ventricular granulomas, can occur in EGPA.
- Early detection of cardiac manifestations is crucial for patient management.
- Routine echocardiographic screening is recommended for EGPA patients to assess cardiac involvement.
Abstract:
Churg-Strauss syndrome (CSS), recently named eosinophilic granulomatosis with polyangiitis (EGPA), is a rare form of systemic vasculitis with extravascular granulomas occurring in patients with asthma and tissue eosinophilia. We represent a large left ventricular granuloma, confirmed by histopathologic evaluation, detected as a ventricular mass by echocardiography in a 45-year-old asthmatic male who was admitted for a cerebrovascular accident. Paraclinical and histopathologic findings confirmed the diagnosis of EGPA. As cardiac involvement in patients with EGPA is associated with poor prognosis, routine echocardiographic evaluation of these patients is suggested.
More Related Videos
Related Concept Videos
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
01:17Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
01:18Disorders of the Autonomic Nervous System
Raynaud's disease, also known as Raynaud's...
01:30Other Disorders of Digestive System
01:18Cardiovascular Drugs: Classification based on Therapeutic Indications
01:29Gastroesophageal Reflux Disease II: Clinical Features and Management
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...