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Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis
Published on: September 26, 2018
Epidemiological Features and Outcomes of COVID-19 in Patients With and Without Cardiovascular Disease
Elahe Piraee1, Habibollah Azarbakhsh2, Ghulam Raza Mohammadyan3
1Social Determinants of Health Research Center, Yasuj University of Medical Sciences, Yasuj, Iran.
Insights
Cardiovascular diseases (CVDs) significantly increase COVID-19 mortality. Patients with CVDs had higher risks of death and more severe symptoms, highlighting the need for targeted prevention and treatment strategies for this vulnerable group.
Area of Science:
- Cardiology
- Infectious Diseases
- Public Health
Background:
- Cardiovascular diseases (CVDs) are established risk factors for severe Coronavirus-19 (COVID-19) progression.
- This study investigated epidemiological differences and outcomes between COVID-19 patients with and without CVDs.
Purpose of the Study:
- To compare epidemiological characteristics and mortality rates in COVID-19 patients with and without pre-existing cardiovascular diseases.
- To identify predictors of mortality in COVID-19 patients, particularly those with CVDs.
Main Methods:
- Retrospective analysis of 1497 COVID-19 patients with CVDs and 26926 without CVDs.
- Comparison of clinical signs, comorbidities, and mortality using Mann-Whitney U test and Pearson's Chi-square test.
- Logistic regression analysis to determine mortality predictors.
Main Results:
- COVID-19 patients with CVDs experienced higher mortality (21.6% of all deaths).
- Symptoms like cough, fever, and shortness of breath were more prevalent in COVID-19 patients with CVDs.
- Underlying CVDs increased the odds of death by 1.9 times, with hypertension and diabetes showing even higher risks (3.4x and 2.1x, respectively).
Conclusions:
- Cardiovascular diseases represent a significant threat, substantially increasing mortality risk in COVID-19 patients.
- Preventive and therapeutic strategies are crucial for managing COVID-19 in patients with CVDs due to their heightened vulnerability and mortality risk.
Background:
Cardiovascular diseases (CVDs) are known as an important group of risk factor for progression of the Coronavirus-19 disease (COVID-19). The present study compared epidemiological features and outcomes in COVID-19 patients with CVDs versus those without CVDs.
Methods:
This is a retrospective study performed on 1497 patients with CVDs and 26926 patients without CVDs, all of whom were confirmed to have COVID-19. All clinical signs and comorbidities were investigated in the subjects. Mann-Whitney U test and Pearson's Chi-square test were applied to compare mortality between the groups. Logistic regression was used to identify the predictors of mortality among patients.
Results:
The mean age of COVID-19 patients with underlying CVD was 60 years. Totally, about 5.3% of the individuals under study had CVD. Also, 21.6% of all deaths occurred in COVID-19 patients with CVD. Cough, fever, shortness of breath, muscle pain, and underlying diseases such as diabetes, hypertension, chronic liver and kidney disease, chronic lung disease, and immunodeficiency were significantly higher in patients with CVD than those without CVDs. The odds of death in COVID-19 patients were 1.9 times higher with underlying CVD, 2.1 times with diabetes, 3.4 times with hypertension, 1.9 times with immunodeficiency, and 2.3 times with chronic liver and kidney disease.
Conclusion:
CVDs are a serious threat to COVID-19 patients because they increase mortality among these patients. As a result, preventive and therapeutic strategies must be developed for these vulnerable groups, who will be prone to higher mortality.
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