Related Experiment Video
Updated: Jul 4, 2025
08:32
Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes
Published on: May 23, 2025
178
CRISPR-Based Therapies: Revolutionizing Drug Development and Precision Medicine
Dilip Kumar Chanchal1,2, Jitendra Singh Chaudhary1, Pushpendra Kumar3
1Department of Pharmacy, Smt. Vidyawati College of Pharmacy, Jhansi, Uttar Pradesh, India.
Current Gene Therapy
|February 4, 2024
Summary
CRISPR gene editing revolutionizes drug discovery and precision medicine. This technology enables personalized therapies and advanced screening for various diseases, with ongoing research and ethical considerations shaping its future applications.
Area of Science:
- Biotechnology
- Genetics
- Pharmacology
Background:
- The advent of CRISPR-Cas9 has significantly impacted drug development and precision medicine.
- CRISPR technology offers unprecedented precision and flexibility in gene editing.
Purpose of the Study:
- To review emerging CRISPR-based therapeutic strategies and their transformative role in medicine.
- To explore the application of CRISPR in drug target identification, validation, and development.
- To discuss the potential of CRISPR for personalized gene therapies and advanced screening techniques.
Main Methods:
- Comprehensive literature review of recent research and clinical trials involving CRISPR technology.
- Analysis of CRISPR's application in treating genetic diseases, cancer, and infectious diseases.
- Examination of ethical and regulatory challenges associated with CRISPR-based therapies.
Main Results:
- CRISPR facilitates novel approaches to drug target discovery and validation.
- CRISPR enables the development of personalized gene therapies for diverse conditions.
- Clinical trials demonstrate CRISPR's potential in treating complex diseases, including genetic disorders and cancer.
Conclusions:
- CRISPR technology is rapidly advancing drug development and precision medicine.
- Ethical and regulatory frameworks are crucial for the safe and responsible implementation of CRISPR therapies.
- The future of medicine is being reshaped by CRISPR's evolving capabilities and applications.
Related Concept Videos
01:59CRISPR
51.0K
Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
51.0K
02:53CRISPR and crRNAs
17.0K
Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...
The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...
17.0K
02:31Homologous Recombination
50.5K
The basic reaction of homologous recombination (HR) involves two chromatids that contain DNA sequences sharing a significant stretch of identity. One of these sequences uses a strand from another as a template to synthesize DNA in an enzyme-catalyzed reaction. The final product is a novel amalgamation of the two substrates. To ensure an accurate recombination of sequences, HR is restricted to the S and G2 phases of the cell cycle. At these stages, the DNA has been replicated already and the...
50.5K
00:49What is Genetic Engineering?
74.1K
Overview
74.1K
02:57Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
02:53Conservative Site-specific Recombination and Phase Variation
6.0K
Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...
The recognition sites for Cre recombinase called LoxP...
6.0K