Cuproptosis Related Gene DLD Associated with Poor Prognosis and Malignant Biological Characteristics in Lung Adenocarcinoma
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Cuproptosis-related genes (CRGs) impact lung adenocarcinoma (LUAD) prognosis. A signature including DLD and LIPT1 predicts survival, with DLD showing therapeutic potential.
Area Of Science
- Cellular Biology
- Oncology
- Genetics
Background
- Cuproptosis is a regulated cell death pathway with implications for cellular function.
- Lung adenocarcinoma (LUAD) is a major form of lung cancer with complex underlying molecular mechanisms.
- Understanding the role of specific genes in LUAD progression is crucial for developing targeted therapies.
Purpose Of The Study
- To investigate the prognostic significance of cuproptosis-related genes (CRGs) in lung adenocarcinoma (LUAD).
- To identify a CRG-based signature for predicting patient outcomes in LUAD.
- To explore the functional role of key CRGs, particularly dihydrolipoamide dehydrogenase (DLD), in LUAD cell behavior.
Main Methods
- Utilized RNA sequencing and clinical data from LUAD patient cohorts.
- Applied LASSO regression and Cox analysis to construct a prognostic CRG signature.
- Performed immunohistochemical analysis and in vitro experiments to assess gene expression and functional impact.
Main Results
- Identified 10 differentially expressed CRGs between LUAD and normal tissues.
- Developed a prognostic signature comprising DLD and LIPT1, where high risk correlated with shorter overall survival (OS).
- Found high DLD and low LIPT1 expression associated with reduced OS; DLD inhibition suppressed LUAD cell proliferation and invasion.
Conclusions
- A prognostic signature based on CRGs, specifically DLD and LIPT1, is identified for LUAD.
- The oncogene DLD demonstrates potential as a therapeutic target for lung adenocarcinoma.
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
Related Concept Videos
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...