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Circadian Rhythms and Gene Regulation

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...

Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

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Related Experiment Video

Updated: Jul 4, 2025

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

Published on: September 28, 2017

Circadian rhythms in solid organ transplantation.

Brielle H Patlin¹, Huram Mok¹, Monaj Arra¹

¹Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri.

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation

|February 4, 2024

Summary

This summary is machine-generated.

Circadian rhythms, daily biological cycles, impact medical treatments. Understanding the molecular clock and its link to organ acceptance may improve solid organ transplantation outcomes.

Keywords:

chronophamacology circadian rhythms immunity ischemia molecular clock time of day transplantation

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Related Experiment Videos

Last Updated: Jul 4, 2025

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

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Published on: September 28, 2017

Author Spotlight: In Vitro Investigations of Circadian Rhythms in Multicellular Systems

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Published on: February 16, 2024

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

Area of Science:

Physiology
Chronobiology
Transplantation Science

Background:

Circadian rhythms are endogenous daily cycles influencing physiological processes.
The molecular clock mechanism regulates these rhythms.
These rhythms can affect the success of medical interventions, including organ transplantation.

Purpose of the Study:

To review the relationship between circadian rhythms and solid organ transplantation.
To explore the molecular clock's role in biological activities relevant to organ acceptance.
To examine clinical evidence linking time of day to transplantation outcomes.

Main Methods:

Literature review of basic research on the molecular clock.
Analysis of biological activities related to organ acceptance.
Review of clinical studies on time-of-day effects in transplantation.

Main Results:

The molecular clock influences biological functions critical for organ acceptance.
Clinical data suggest a correlation between the timing of transplantation and adverse outcomes.
Significant knowledge gaps exist in applying circadian biology to transplantation.

Conclusions:

Circadian biology is a relevant factor in solid organ transplantation.
Further research is needed to bridge basic science and clinical application.
Leveraging circadian rhythms holds potential for improving transplantation success.