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Updated: Jul 4, 2025
Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
Published on: March 20, 2020
Filamin A in triple negative breast cancer
Pia Giovannelli1, Marzia Di Donato1, Fabrizio Licitra1
1Department of Precision Medicine, University of Campania "L.Vanvitelli", Via L. De Crecchio, 7-80138 Naples, Italy.
Abstract:
Triple-negative breast cancer is a rare but highly heterogeneous breast cancer subtype with a limited choice of specific treatments. Chemotherapy remains the only efficient treatment, but its side effects and the development of resistance consolidate the urgent need to discover new targets. In TNBC, filamin A expression correlates to grade and TNM stage. Accordingly, this protein could constitute a new target for this BC subtype. Even if most of the data indicates its direct involvement in cancer progression, some contrasting results underline the need to deepen the studies. To elucidate a possible function of this protein as a TNBC marker, we summarized the main characteristic of filamin A and its involvement in physiological and pathological processes such as cancer. Lastly, we scrutinized its actions in triple-negative breast cancer and highlighted the need to increase the number of studies useful to better clarify the role of this versatile protein as a marker and target in TNBC, alone or in "collaboration" with other proteins with a relevant role in this BC subgroup.
Insights
Filamin A may be a new therapeutic target for triple-negative breast cancer (TNBC). Further research is needed to clarify its role as a marker and target in TNBC treatment.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- Triple-negative breast cancer (TNBC) is a heterogeneous subtype with limited targeted treatment options.
- Chemotherapy is the primary treatment, but resistance and side effects necessitate new therapeutic targets.
- Filamin A expression is linked to TNBC grade and stage, suggesting its potential as a therapeutic target.
Purpose of the Study:
- To investigate the potential of filamin A as a biomarker and therapeutic target in TNBC.
- To review the known characteristics of filamin A and its role in cancer.
- To analyze filamin A's specific functions in triple-negative breast cancer.
Main Methods:
- Literature review and analysis of existing data on filamin A.
- Summarization of filamin A's physiological and pathological roles, particularly in cancer.
- Scrutiny of filamin A's involvement in triple-negative breast cancer.
Main Results:
- Filamin A expression correlates with TNBC grade and TNM stage.
- Existing data suggest filamin A's involvement in cancer progression, though some results are contradictory.
- The precise role of filamin A in TNBC requires further investigation.
Conclusions:
- Filamin A presents a potential new target for triple-negative breast cancer.
- Additional studies are essential to fully elucidate filamin A's function as a marker and target in TNBC.
- Filamin A's collaborative role with other proteins in TNBC warrants further exploration.
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