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Related Concept Videos

Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

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Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
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Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

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The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
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Heart Failure Drugs: Inotropic Agents01:26

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Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
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Methods Of Healthcare Delivery System01:26

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At the different levels of the healthcare system, we see varying methods of healthcare used. These methods include managed care systems, case management, and primary healthcare.
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Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
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Heart Failure Drugs: β-Blockers01:22

Heart Failure Drugs: β-Blockers

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β-adrenergic antagonists, commonly known as β-blockers, block the effects of sympathetic neurotransmitters such as noradrenaline (NA) and adrenaline (ADR). They have several beneficial effects in heart failure treatment. They reduce heart rate, the force of contraction, and cardiac muscle relaxation. They also slow the atrial-ventricular conduction rate and raise the threshold for arrhythmias. The concentration of β-blockers determines their effects on bronchodilation,...
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Related Experiment Video

Updated: Jul 4, 2025

Author Spotlight: Workflow for Integrating POCUS Data into EHR for Managing Heart Failure Patients
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New models for heart failure care delivery.

Jeffrey Xia1, Nicholas K Brownell2, Gregg C Fonarow2

  • 1Department of Medicine David Geffen School of Medicine at UCLA, Los Angeles, United States of America.

Progress in Cardiovascular Diseases
|February 4, 2024
PubMed
Summary

Optimizing heart failure (HF) treatment with guideline-directed medical therapies (GDMT) is crucial. HF implementation strategies across inpatient, discharge, and outpatient settings aim to improve patient outcomes and reduce hospitalizations.

Keywords:
DischargeGuideline directed medical therapyHeart failureImplementationInpatientOutpatient

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Area of Science:

  • Cardiology
  • Healthcare Management
  • Implementation Science

Background:

  • Heart failure (HF) is a global health concern with rising prevalence.
  • Poorly controlled HF leads to high morbidity, mortality, rehospitalization, and healthcare costs.
  • Despite proven guideline-directed medical therapies (GDMT), clinical inertia hinders optimal HF management, with few patients receiving all four GDMT classes.

Purpose of the Study:

  • To highlight the critical need for HF implementation strategies.
  • To bridge the gap between HF patients and essential GDMT.
  • To explore various modalities for improving HF management.

Main Methods:

  • HF implementation strategies are categorized by care setting: inpatient, discharge, and outpatient.
  • Inpatient strategies include rapid GDMT titration, audit-and-feedback, virtual teams, and EHR alerts.
  • Discharge strategies involve patient/provider education, summaries, and transitional programs.
  • Outpatient strategies encompass digital tools, population management, team restructuring, remote monitoring, and hospital-at-home models.

Main Results:

  • Various innovative strategies exist for HF implementation across different care stages.
  • These strategies aim to improve GDMT optimization and overall HF care.
  • The study underscores the need for novel implementation and monitoring methods due to the growing HF population.

Conclusions:

  • Effective HF implementation is vital to address the gap in GDMT optimization.
  • A multi-faceted approach addressing inpatient, discharge, and outpatient settings is necessary.
  • Continuous innovation in HF implementation and monitoring is required to manage the increasing burden of heart failure.