Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

419
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
419
Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

276
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
276
Anatomy of the Intestines01:23

Anatomy of the Intestines

72.0K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
72.0K
Male Sexual Response: Erection & Ejaculation01:17

Male Sexual Response: Erection & Ejaculation

2.3K
Sexual stimulation can take various forms, such as physical touch and visual or auditory cues. When this happens, the parasympathetic reflex in the sacral portion of the spinal cord is activated. This reflex stimulates the release of nitric oxide (NO), which then dilates the arterioles in the penis, increasing blood flow to the erectile tissues - the corpora cavernosa and corpus spongiosum.
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...
2.3K
Bacterial Flora of the Large Intestine01:29

Bacterial Flora of the Large Intestine

451
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
451

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Endothelial activation and stress index is independently associated with arteriogenic erectile dysfunction: a cross-sectional study.

Sexual medicine·2026
Same author

Chronic stress drives oligoasthenozoospermia via gut microbiota-vitamin-Sting1/Slc9c2 axis.

Nature communications·2026
Same author

Quality and readability of online penile-cancer information: a Cross-Sectional Web Study.

International journal of impotence research·2026
Same author

Altered Glutamate and Gamma-Aminobutyric Acid Metabolism in the Thalamus and Prefrontal Cortex of Patients with Lifelong Premature Ejaculation.

The world journal of men's health·2026
Same author

Lower eGFR Associated With Decreased Total Testosterone in Males: Integrated Evidence From Cohorts to Real-World Data.

Andrology·2026
Same author

Chronotype is associated with acquired premature ejaculation: evidence from moderated mediation analysis.

The journal of sexual medicine·2026

Related Experiment Video

Updated: Jul 4, 2025

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

28.0K

The Association between the Gut Microbiota and Erectile Dysfunction.

Tianle Zhu1, Xi Liu1, Peng Yang1

  • 1Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

The World Journal of Men'S Health
|February 4, 2024
PubMed
Summary

This study reveals a causal link between gut bacteria and erectile dysfunction (ED). Specific bacteria like Lachnospiraceae increase ED risk, while Ruminococcaceae may offer protection, suggesting potential microbiome interventions.

Keywords:
CausalityErectile dysfunctionGastrointestinal microbiomeMendelian randomization analysisMetabolism

More Related Videos

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
05:41

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Published on: April 6, 2022

2.9K

Related Experiment Videos

Last Updated: Jul 4, 2025

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

28.0K
Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
05:41

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Published on: April 6, 2022

2.9K

Area of Science:

  • Microbiome Research
  • Human Health
  • Genetics

Background:

  • Erectile dysfunction (ED) is a prevalent condition with multifactorial causes.
  • The gut microbiota plays a crucial role in host health and disease.
  • Understanding the gut microbiota's influence on ED is essential for developing novel therapeutic strategies.

Purpose of the Study:

  • To investigate the causal relationship between human gut microbiota composition and erectile dysfunction (ED).
  • To identify specific bacterial taxa at various taxonomic levels (phylum to genus) associated with ED risk.
  • To explore potential pathogenic bacteria contributing to ED onset and progression.

Main Methods:

  • Utilized genetic variation data from the MiBioGen Consortium's human gut microbiome Genome Wide Association Studies (GWAS) dataset.
  • Extracted GWAS statistics for ED from a large-scale study including 223,805 participants.
  • Performed Mendelian randomization (MR) analysis, including bidirectional MR, to establish causality and directionality between gut microbiota and ED.

Main Results:

  • Identified a causal association between the family Lachnospiraceae and an increased risk of ED (OR: 1.27, p=0.01).
  • Found that specific genera, including Oscillibacter (OR: 1.17, p=0.03), Senegalimassilia (OR: 1.32, p=0.01), and Tyzzerella3 (OR: 1.14, p=0.02), are linked to higher ED risk.
  • Discovered a protective effect of the genus RuminococcaceaeUCG013 against ED (OR: 0.77, p=0.02).

Conclusions:

  • Preliminary identification of six bacterial taxa with a potential causal link to ED.
  • The identified taxa, including Lachnospiraceae, Oscillibacter, Senegalimassilia, Tyzzerella 3, and Ruminococcaceae UCG013, represent potential targets for future ED microbiome interventions.
  • This research provides a foundation for exploring microbiome-based therapeutic approaches for managing erectile dysfunction.