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Updated: Jul 4, 2025

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
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In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

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A therapeutical insight into the correlation between circRNAs and signaling pathways involved in cancer pathogenesis

Raed Obaid Saleh1, Sulieman Ibraheem Shelash Al-Hawary2, Saade Abdalkareem Jasim3

  • 1Department of Medical Laboratory Techniques, Al-Maarif University College, Al-Anbar, Iraq.

Medical Oncology (Northwood, London, England)
|February 4, 2024
PubMed

Insights

Circular RNAs (circRNAs) have vital roles in cell functions and disease. This review explores their involvement in cancer, highlighting their potential as diagnostic biomarkers and therapeutic targets.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Circular RNAs (circRNAs) are non-coding RNA molecules formed from back-splicing of pre-messenger RNA.
  • CircRNAs perform critical biological functions, including acting as miRNA sponges, modulating protein activity, and serving as translation templates.
  • Dysregulated circRNA expression is linked to various diseases, particularly cancer, due to the disruption of molecular pathways maintaining homeostasis.

Purpose of the Study:

  • To review the biological and carcinogenic effects of circRNAs in cancer.
  • To highlight the involvement of circRNAs in signal transduction pathways.
  • To explore the potential of circRNAs as novel biomarkers for early cancer detection and prognosis.

Main Methods:

  • Literature review of studies on circRNA biogenesis, function, and role in cancer.
  • Analysis of circRNA involvement in key cancer-related molecular pathways.
  • Evaluation of current evidence for circRNAs as cancer biomarkers.

Main Results:

  • CircRNAs exhibit diverse functions, impacting gene regulation and protein interactions.
  • Aberrant circRNA expression is a hallmark of many cancers, affecting cellular processes.
  • CircRNAs play roles in various cancer-related signal transduction pathways.

Conclusions:

  • CircRNAs are critical players in cancer development and progression.
  • CircRNAs hold significant promise as biomarkers for early cancer diagnosis and prognosis.
  • Targeting circRNAs presents a potential therapeutic strategy for cancer treatment.
Keywords:
CancerCirc-RNAsNon-coding RNAsSignaling pathways

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