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HIV Associated Lymphomas: A Double-Edged Sword.

Reema Singh1, Jyotsna Kapoor1, Nisha Panwar1

  • 1Department of Hematology and Bone Marrow Transplant Unit, Rajiv Gandhi Cancer Institute and Research Centre, Sector 5, Rohini, Delhi, 110085 India.

Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion
|February 5, 2024
PubMed
Summary
This summary is machine-generated.

People with HIV (human immunodeficiency virus) face increased lymphoma risk. This study shows HIV-associated lymphomas have an acceptable prognosis, with 10-year survival rates around 79%, even with advanced disease.

Keywords:
CD4 countsHIV positiveLymphomaSurvival

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Area of Science:

  • Oncology
  • Infectious Diseases
  • Hematology

Background:

  • People with HIV (human immunodeficiency virus) have a higher risk of developing lymphomas compared to the general population.
  • This elevated risk persists even during the highly active antiretroviral therapy (HAART) era.

Purpose of the Study:

  • To retrospectively analyze the outcomes of patients with HIV-associated lymphomas.
  • To evaluate overall response rate (ORR), overall survival (OS), and event-free survival (EFS) in this cohort.

Main Methods:

  • Retrospective analysis of 23 patients with HIV-associated lymphomas between January 2012 and October 2022.
  • Statistical analysis included Kaplan-Meier for survival and chi-square for disease response factors.
  • Minimum follow-up of 6 months was required.

Main Results:

  • The majority of patients (57.9%) presented with stage 4 disease.
  • Diffuse large B-cell lymphoma (DLBCL) was most common, with 60% achieving complete remission (CR) post-first-line chemotherapy.
  • At last follow-up, 78.95% of patients were alive, with a 10-year OS and progression-free survival (PFS) of 78.95% ± 11%.

Conclusions:

  • HIV-associated lymphomas demonstrate an acceptable prognosis.
  • Favorable outcomes are achievable despite advanced stage at presentation, lower CD4 counts, and concurrent antiretroviral therapy (ART).
  • Intensive chemotherapy contributes to positive treatment results.