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Association of Circulating Carbohydrate Antigen 19-9 Level with Type 2 Diabetic Kidney Disease in Chinese Adults: A

Pijun Yan1,2,3,4,5, Jia Li1,2,3,4,5, Yi Zhang1,2,3,4,5

  • 1Department of Endocrinology and Metabolism, the Affiliated Hospital of Southwest Medical University, Luzhou, People's Republic of China.

Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy
|February 5, 2024
PubMed

Insights

High levels of carbohydrate antigen 19-9 (CA19-9) are linked to diabetic kidney disease (DKD) in Chinese patients with type 2 diabetes mellitus (T2DM). CA19-9 may be a useful biomarker for detecting DKD in this population.

Area of Science:

  • Endocrinology
  • Nephrology
  • Oncomarkers

Background:

  • Limited data exist on the association between carbohydrate antigen 19-9 (CA19-9) and diabetic kidney disease (DKD).
  • Existing studies present conflicting information regarding CA19-9 levels in relation to DKD components like albuminuria and estimated glomerular filtration rate (eGFR).

Purpose of the Study:

  • To investigate the correlation between circulating CA19-9 levels and the presence of DKD.
  • To evaluate CA19-9 as a potential biomarker for DKD in Chinese patients diagnosed with type 2 diabetes mellitus (T2DM).

Main Methods:

  • A cross-sectional study involving 402 hospitalized T2DM patients.
  • Serum CA19-9 levels were measured using a chemiluminescence method.
  • Statistical analyses included multivariate logistic regression, correlation, and receiver operating characteristic (ROC) curve analysis.

Main Results:

  • T2DM patients with DKD exhibited significantly higher serum CA19-9 levels compared to those without DKD.
  • Serum CA19-9 levels positively correlated with urinary albumin-to-creatinine ratio and negatively with eGFR.
  • Elevated CA19-9 was identified as an independent risk factor for DKD, with higher quartiles showing a progressively increased risk.

Conclusions:

  • High circulating CA19-9 levels are associated with DKD in hospitalized Chinese T2DM patients.
  • CA19-9 demonstrates potential as a valuable biomarker for the early detection or assessment of DKD in this patient cohort.
Abstract

Keywords:
Chinese populationcarbohydrate antigen 19-9diabetic kidney diseaseestimated glomerular filtration rateurinary albumin-to-creatinine ratio

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