Coupling allows robust mammalian redox circadian rhythms despite heterogeneity and noise
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View abstract on PubMed
Summary
This summary is machine-generated.Noise and cell variability can disrupt circadian clocks. However, coupling these cellular oscillators can restore robust daily rhythms, demonstrating how cells overcome internal randomness for synchronized physiological functions.
Area Of Science
- * Biochemistry and Molecular Biology
- * Systems Biology
- * Chronobiology
Background
- * Circadian clocks are intrinsic cellular timekeepers regulating daily physiological and behavioral rhythms.
- * Mammalian circadian rhythms are generated by transcription-translation feedback loops (TTFL) and redox reactions.
- * Both TTFL and redox mechanisms exhibit inherent stochasticity and heterogeneity at the single-cell level.
Purpose Of The Study
- * To investigate how noise and heterogeneity influence redox oscillators in circadian rhythms.
- * To explore the emergent properties of coupled stochastic redox oscillators.
- * To understand the interplay between redox oscillators and TTFL in circadian rhythm generation.
Main Methods
- * Simplified a kinetic model of redox oscillations into an amplitude-phase oscillator with 'twist'.
- * Introduced Gaussian noise to simulate stochasticity and heterogeneity.
- * Analyzed the effects of coupling between oscillators and integration with a TTFL model.
Main Results
- * Noise and heterogeneity alone cause rapid desynchronization of oscillators.
- * Coupling between noisy oscillators leads to robust synchronization, amplitude expansion, and period tuning via 'twist'.
- * Integrating redox oscillators with a TTFL model enhances synchronization and amplitude, and fine-tunes the period.
Conclusions
- * Coupling is crucial for establishing synchronized circadian rhythms despite intracellular noise and heterogeneity.
- * The 'twist' mechanism in redox oscillators contributes to period tuning.
- * These findings illuminate how circadian systems achieve robustness against stochasticity.
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