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Updated: Jul 4, 2025

Evaluation of Substrate Ubiquitylation by E3 Ubiquitin-ligase in Mammalian Cell Lysates
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Diverse roles of UBE2S in cancer and therapy resistance: Biological functions and mechanisms

Mengjun Zhang1, Jialin Wang2, Zidi Zhang1

  • 1Department of Gynecology, The Third Affiliated Hospital of Zhengzhou University, 7 Rehabilitation Front Street, Zhengzhou 450052, China.

Heliyon
|February 5, 2024
PubMed

Insights

Ubiquitin Conjugating Enzyme E2 S (UBE2S) is vital in cancer development and treatment resistance. This review explores UBE2S

Area of Science:

  • Biochemistry and Molecular Biology
  • Oncology
  • Epigenetics

Background:

  • Ubiquitin Conjugating Enzyme E2 S (UBE2S) is involved in substrate ubiquitination.
  • UBE2S is implicated in various diseases, including cancer, myocardial ischemia, and viral hepatitis.
  • Its role in human malignancies like breast, lung, and liver cancer is increasingly recognized.

Purpose of the Study:

  • To provide a comprehensive review of UBE2S in human tumor research.
  • To analyze UBE2S' structural characteristics and biomarker potential in cancer.
  • To examine UBE2S' role in tumor treatment resistance.

Main Methods:

  • Literature review and analysis of existing studies on UBE2S.
  • Examination of structural data and functional roles of UBE2S.
  • Synthesis of evidence regarding UBE2S' involvement in cancer progression and treatment.

Main Results:

  • UBE2S exhibits potential as a diagnostic biomarker across various cancer types.
  • UBE2S contributes to resistance against established tumor therapies.
  • Structural and functional insights into UBE2S' oncogenic activities are presented.

Conclusions:

  • UBE2S is a promising therapeutic target for multiple human malignancies.
  • Targeting UBE2S may offer novel strategies for overcoming cancer treatment resistance.
  • Further research into UBE2S is warranted for its clinical application in oncology.
Keywords:
Biological functionMechanismPan-cancerTherapy resistanceUBE2S

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