Does Walking Have an Association with Osteoarthritis? A Two-Sample Mendelian Randomization Analysis.
Jiankang Xu1,2, Longyao Zhang1,2, Ping Wang1,2
1Orthopedics Department, The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, People's Republic of China.
Clinical Interventions in Aging
|February 5, 2024
Summary
Leisure walking shows a genetic link to a reduced risk of knee osteoarthritis (KOA). However, this genetic association was not found for hip osteoarthritis (HOA).
Area of Science:
- Genetics
- Epidemiology
- Orthopedics
Background:
- Osteoarthritis (OA) is a leading cause of disability.
- Previous research suggests a link between walking and OA.
- Genetic evidence supporting this association is limited.
Purpose of the Study:
- To investigate the genetic relationship between walking for pleasure and osteoarthritis (OA).
- To differentiate the genetic correlation for knee osteoarthritis (KOA) and hip osteoarthritis (HOA).
Main Methods:
- Utilized publicly available Genome-Wide Association Study (GWAS) data.
- Employed inverse variance weighting (IVW) as the primary Mendelian randomization (MR) analysis method.
- Conducted secondary analyses using MR-Egger, Weighted median, Simple mode, and Weighted mode, alongside heterogeneity and pleiotropy tests.
Main Results:
- Mendelian randomization analysis revealed a significant negative correlation between walking for pleasure and overall OA (KOA or HOA) (OR = 0.3224, P = 0.0181).
- Specifically, walking for pleasure was negatively correlated with knee osteoarthritis (KOA) (OR = 0.1396, P = 0.0003).
- No statistically significant correlation was found between walking for pleasure and hip osteoarthritis (HOA) (OR = 1.2075, P = 0.8381).
Conclusions:
- Genetic evidence indicates that walking for pleasure is associated with a reduced risk of knee osteoarthritis (KOA).
- The current genetic analysis does not provide clear evidence for a similar association with hip osteoarthritis (HOA).
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