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A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes
Published on: September 15, 2018
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Lipoprotein(a) in Familial Hypercholesterolemia
Erin O Jacob1,2, Adam D McIntyre2, Jian Wang2
1Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
CJC Open
|February 5, 2024
Summary
Lipoprotein (a) levels are independent of low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol. Measuring lipoprotein (a) separately is crucial for assessing atherosclerotic risk in hypercholesterolemia patients.
Area of Science:
- Cardiovascular Medicine
- Lipidology
- Genetics
Background:
- Low-density lipoprotein (LDL) and Lipoprotein (Lp)(a) are proatherogenic particles containing apolipoprotein B.
- Elevated LDL cholesterol (C), non-HDL-C, and apo B characterize heterozygous familial hypercholesterolemia (HeFH), but Lp(a) levels are inconsistently reported.
Purpose of the Study:
- To investigate the relationship between plasma levels of Lp(a) and LDL-C, non-HDL-C, and apo B in patients with hypercholesterolemia.
- To determine if Lp(a) levels are elevated in patients with genetically confirmed HeFH.
Main Methods:
- Retrospective chart review of 256 genetically characterized hypercholesterolemia patients and 272 controls.
- Analysis of pairwise correlations between plasma Lp(a) and LDL-C, non-HDL-C, and apo B levels.
Main Results:
- Mean Lp(a) levels did not differ between hypercholesterolemia patients and controls.
- No significant correlations were found between Lp(a) and LDL-C or non-HDL-C in either group.
- Weak correlations were observed between Lp(a) and apo B in patients (r=0.103, P=0.112) and controls (r=0.175, P=0.005).
Conclusions:
- Lp(a) levels are independent of LDL-C and non-HDL-C, and are not elevated in HeFH patients.
- Apo B shows only a weak association with Lp(a).
- Lp(a) must be measured separately to assess its impact on atherosclerotic risk in hypercholesterolemia, as it is not predictable from LDL-C.
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