Optimal dosage protocols for mathematical models of synergy of chemo- and immunotherapy
Urszula Ledzewicz1,2, Heinz Schättler3
1Institute of Mathematics, Lodz University of Technology, Lodz, , Poland.
Abstract:
The release of tumor antigens during traditional cancer treatments such as radio- or chemotherapy leads to a stimulation of the immune response which provides synergistic effects these treatments have when combined with immunotherapies. A low-dimensional mathematical model is formulated which, depending on the values of its parameters, encompasses the 3 E's (elimination, equilibrium, escape) of tumor immune system interactions. For the escape situation, optimal control problems are formulated which aim to revert the process to the equilibrium scenario. Some numerical results are included.
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