Recent progress in functional metal-organic frameworks for bio-medical application.

Area of Science:

• Materials Science
• Biomedical Engineering
• Nanotechnology

Background:

• Metal-organic frameworks (MOFs) possess high surface area and tunable pores, enabling the creation of functional porous materials.
• Functionalized MOFs are being developed as advanced drug carriers with targeted delivery and responsive release capabilities.
• MOFs show promise in bio-detection, disease therapy, and tissue healing.

Purpose of the Study:

• To review the functionalization strategies for MOFs in biomedical engineering.
• To evaluate the role of MOF functionalization in enhancing material reactivity.
• To survey the applications of functionalized MOF composites in various biomedical fields.

Main Methods:

• Physical binding and chemical cross-linking of small molecules, polymers, biomacromolecules, and hydrogels to MOFs.
• Analysis of MOF functionalization approaches to boost material reactivity.
• Survey of literature on functionalized MOF applications in drug delivery, tissue repair, disease treatment, bio-detection, and imaging.

Main Results:

• Functionalization enhances MOFs' dispersion and functionalities for biomedical uses.
• MOFs can be modified to achieve targeted drug delivery and controlled release.
• Functionalized MOFs are effective in bio-detection, tissue engineering, and therapeutic applications.

Conclusions:

• Functionalized MOFs represent a significant new class of biomedical materials.
• Continued research into MOF functionalization will drive innovation in healthcare.
• MOFs hold substantial promise for future bio-medical applications and advancements.