Prediabetes: An overlooked risk factor for major adverse cardiac and cerebrovascular events in atrial fibrillation...

Area of Science:

• Cardiology
• Endocrinology
• Public Health

Background:

• Prediabetes is a known risk factor for major adverse cardiac and cerebrovascular events (MACCE).
• The association between prediabetes and MACCE in patients with atrial fibrillation (AF) is not well-established.
• This study addresses this knowledge gap by investigating the link between prediabetes and MACCE in AF patients.

Purpose of the Study:

• To investigate the association between prediabetes and MACCE in patients hospitalized with atrial fibrillation (AF).

Main Methods:

• Utilized the 2019 National Inpatient Sample database.
• Identified hospitalizations with AF using ICD-10 CM codes, categorizing patients into prediabetes and non-prediabetes groups (excluding diabetics).
• Primary outcome was MACCE, including all-cause inpatient mortality, cardiac arrest, and stroke.

Main Results:

• Prediabetes was associated with a higher rate of MACCE in AF patients (18.6% vs. 14.7%).
• Adjusted analysis revealed significantly higher odds of MACCE in the prediabetes group (OR 1.34, 95% CI 1.26-1.42).
• Subgroup analyses indicated stronger associations in males, Hispanics, and Asians.

Conclusions:

• A significant association exists between prediabetes and MACCE in AF patients.
• Highlights the need for active screening and management of prediabetes in AF populations.
• Suggests prediabetes management as a potential strategy to reduce MACCE in AF patients.