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Biomarkers That Predict Crohn's Disease Outcomes
Pablo A Olivera1,2, Mark S Silverberg1,2
1Zane Cohen Centre for Digestive Diseases, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Journal of the Canadian Association of Gastroenterology
|February 5, 2024
Summary
Identifying biomarkers for Crohn's disease (CD) outcomes is crucial for personalized treatment. This review highlights promising markers like pharmacogenomic, transcriptomic, and microbiome signatures to guide therapy and predict complications.
Area of Science:
- Gastroenterology
- Immunology
- Genetics
Background:
- Crohn's disease (CD) is a chronic inflammatory digestive condition with complex prognosis and treatment challenges.
- Current prognostic factors have limitations, necessitating more precise biomarkers for early-stage and treatment-naive patients.
Purpose of the Study:
- To review and summarize current literature on promising biomarkers for predicting Crohn's disease outcomes.
- To discuss the potential clinical implications of these biomarkers in tailoring treatment and managing the disease.
Main Methods:
- Literature review of studies identifying biomarkers associated with CD prognosis, treatment response, and complications.
- Focus on pharmacogenomic, molecular, imaging, and microbiome-based markers.
Main Results:
- Pharmacogenomic markers (TPMT, NUDT15) predict thiopurine adverse events.
- HLA haplotypes, oncostatin M, and transcriptomic profiles correlate with anti-TNF therapy response.
- Confocal laser endomicroscopy, single-cell analyses, microbiome signatures, and proteomic profiles show potential for predicting treatment response and post-operative recurrence.
Conclusions:
- Biomarkers offer significant potential to personalize Crohn's disease management, improving treatment selection and outcome prediction.
- Further research and clinical validation are essential for integrating these biomarkers into routine patient care.
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