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Zinc-Boron Complex-Based Dietary Supplements for Longevity and Healthy Life
Andrei Biţă1,2, Ion Romulus Scorei1, Tudor Adrian Bălşeanu1,3
1Department of Biochemistry, BioBoron Research Institute, S.C. Natural Research S.R.L., Podari, Dolj County, Romania.
Current Health Sciences Journal
|February 5, 2024
Summary
Zinc-Boron Complex (ZBC) dietary supplements are stable, non-toxic, and well-absorbed, promoting longevity by increasing alpha2-macroglobulin (A2M) expression. ZBC is rapidly metabolized and excreted, with peak A2M levels observed in chronic studies.
Area of Science:
- Nutritional Science
- Biochemistry
- Toxicology
Background:
- Zinc (Zn) and Boron (B) play crucial roles in the plant-animal-human nutritional pathway.
- Investigating novel formulations for essential mineral delivery is a global research priority.
Purpose of the Study:
- To evaluate the nutritional and physiological effects of a Zinc-Boron Complex (ZBC) dietary supplement.
- To assess the safety, absorption, metabolism, and excretion profile of ZBC.
- To determine the impact of ZBC on alpha2-macroglobulin (A2M) expression for potential health benefits.
Main Methods:
- Development and characterization of Zinc-Boron Complex (ZBC) based dietary supplements.
- Administration of ZBC to mice in acute, subchronic, and chronic experimental settings.
- Assessment of intestinal absorption, metabolism, urinary excretion, and hepatic A2M protein levels via immunoabsorbance assay.
Main Results:
- ZBC formulations demonstrated stability, non-toxicity, and high intestinal absorption rates.
- ZBC was rapidly metabolized by hydrolysis and primarily excreted in urine within seven hours.
- Significant induction of hepatic A2M protein was observed, with the highest levels in the chronic experiment (1000mg/kg).
Conclusions:
- Zinc-Boron Complex (ZBC) represents a promising, bioavailable, and safe dietary supplement.
- ZBC administration effectively induces alpha2-macroglobulin (A2M) expression, suggesting potential for promoting longevity and healthy aging.
- The rapid metabolism and excretion profile of ZBC supports its safety for oral supplementation.
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