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Mild asthma is not mild: risk factors and predictive biomarkers for severe acute exacerbations and progression in

Lingling Wang¹, Ling Zhou¹, Pengdou Zheng¹

¹Department of Respiratory and Critical Care Medicine, Key Laboratory of Pulmonary Diseases of Health Ministry, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Expert Review of Respiratory Medicine

|February 5, 2024

Abstract

Introduction:

Asthma is a common chronic respiratory disease characterized by chronic airway inflammation, airway hyperresponsiveness, reversible airflow limitation, and airway remodeling. Mild asthma is the most common type of asthma, but it is the most neglected. Sometimes mild asthma can lead to acute severe exacerbations or even death.

Areas Covered:

This article reviews the epidemiology, risk factors, and possible predictors of acute severe exacerbations and disease progression in mild asthma to improve the understanding of mild asthma and its severe acute exacerbations and progression.

Expert Opinion:

There is a necessity to improve asthma patient categorization and redefine mild asthma's concept to heighten patient and physician attention. Identifying mild asthma patients that are highly vulnerable to severe acute exacerbations and researching the mechanisms are future prioritizations.

Keywords:

Mild asthma Overuse of short-acting beta-agonis Risk factors biomarkers severe acute exacerbations

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