Preoperative low plasma creatine kinase levels predict worse survival outcomes in bladder cancer after radical cystectomy
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View abstract on PubMed
Summary
This summary is machine-generated.Preoperative low creatine kinase (CK) levels independently predict worse survival outcomes in bladder cancer (BCa) patients after radical cystectomy (RC). Lower CK levels indicate a higher risk of recurrence and mortality.
Area Of Science
- Oncology
- Biochemistry
- Surgical Outcomes
Background
- Bladder cancer (BCa) prognosis after radical cystectomy (RC) requires improved predictive markers.
- Preoperative creatine kinase (CK) levels are increasingly recognized for their potential role in cancer prognostication.
Purpose Of The Study
- To investigate the prognostic value of preoperative creatine kinase (CK) levels in patients undergoing radical cystectomy (RC) for bladder cancer (BCa).
Main Methods
- A cohort of 570 BCa patients who underwent RC between 2010 and 2020 was analyzed.
- Logistic and Cox regression models assessed the association between CK levels (cutoff 108.5 U/L) and oncologic outcomes.
- Subgroup analyses were conducted to control for potential confounding factors.
Main Results
- Lower preoperative CK levels were significantly associated with worse recurrence-free survival (RFS) and overall survival (OS).
- Multivariate analysis confirmed low preoperative CK levels as an independent predictor of poorer RFS (HR: 1.683) and OS (HR: 1.567).
Conclusions
- Preoperative creatine kinase (CK) levels serve as an independent prognostic indicator for survival in bladder cancer (BCa) patients post-radical cystectomy (RC).
- Integrating preoperative CK levels into existing prediction models may enhance risk stratification for BCa patients.
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