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B10 cells: Development, phenotype, and function in cancer.

Dandan Li1, Yunfeng Ma1

  • 1Department of Pathogenic Biology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Centre, China.

Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University
|February 5, 2024
PubMed
Summary
This summary is machine-generated.

Regulatory B cells, known as B10 cells, suppress anti-tumor immunity by secreting IL-10. Understanding B10 cells is crucial for developing new cancer immunotherapies to target tumor immune evasion.

Keywords:
B10 cellsIL-10cancertumor immunology

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Area of Science:

  • Immunology
  • Oncology
  • Cell Biology

Background:

  • B10 cells are regulatory B cells found in mice and humans.
  • They secrete interleukin-10 (IL-10), an anti-inflammatory cytokine.
  • B10 cells play a key role in balancing anti-tumor immunity and tumor promotion.

Purpose of the Study:

  • To review the ontogeny, phenotype, and functions of B10 cells in mice.
  • To examine the role of B10 cells in animal cancer models.
  • To extend these findings to the human clinical context and their role in tumor immune evasion.

Main Methods:

  • Literature review of murine B10 cell biology.
  • Analysis of studies on B10 cells in oncological animal models.
  • Extrapolation of findings to human cancer immunology.

Main Results:

  • B10 cells act as key suppressors of anti-tumor immunity.
  • They collaborate with other immune cells to promote tumor growth and metastasis.
  • B10 cells contribute to tumor immune evasion in both animal models and humans.

Conclusions:

  • B10 cells are critical mediators of tumor immune evasion.
  • Targeting B10 cell activity is a promising strategy for enhancing cancer immunotherapy.
  • Further research into B10 cell function is essential for advancing cancer treatment.