Blockchain-Based Dynamic Consent and its Applications for Patient-Centric Research and Health Information Sharing:...

Area of Science:

• Health Informatics
• Blockchain Technology
• Research Ethics

Background:

• Blockchain offers potential for patient-centric health research and information sharing.
• Dynamic informed consent, enabled by blockchain, allows continuous patient oversight of data usage.
• Current implementations of blockchain-based dynamic consent in health research require critical evaluation.

Purpose of the Study:

• To guide the identification and critical appraisal of blockchain-based dynamic consent implementations in health research.
• To facilitate the development of best practices for future research, innovation, and implementation.

Main Methods:

• An integrative review protocol based on the PRISMA-P framework.
• Comprehensive literature searches across multiple academic and gray literature databases.
• Independent data extraction and adjudication by multiple reviewers, with quality appraisal using the Mixed Method Appraisal Tool and thematic synthesis.

Main Results:

• Initial searches identified 492 articles, with 180 selected for full-text review, confirming sufficient literature for feasibility.
• The review will synthesize evidence on the effectiveness, efficiency, satisfaction, and regulatory compliance of blockchain-based dynamic consent.
• Methods for identity management in blockchain-based consent systems will also be analyzed.

Conclusions:

• The review will provide a comprehensive overview of emerging blockchain-based dynamic consent technologies in health research.
• Insights will inform best practices to enhance patient-centric research and health information sharing.
• This work supports ethical and compliant longitudinal research and patient engagement.