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Related Concept Videos

Crossing Over01:34

Crossing Over

Unlike mitosis, meiosis aims for genetic diversity in its creation of haploid gametes. Dividing germ cells first begin this process in prophase I, where each chromosome—replicated in S phase—is now composed of two sister chromatids (identical copies) joined centrally.
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process called synapsis.
In order to...
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Types of Genetic Transfer Between Organisms02:18

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Genetic transfer occurs when genetic information is passed from one organism to another. It occurs via two mechanisms: vertical gene transfer and horizontal gene transfer. Vertical gene transfer occurs when genetic information is transferred from one generation to the next, which happens much more frequently than horizontal gene transfer. Both sexual and asexual reproduction are forms of vertical gene transfer, where one or more organisms pass some or all of their genome onto their progeny.
Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
Types of Genetic Transfer Between Organisms02:18

Types of Genetic Transfer Between Organisms

Genetic transfer occurs when genetic information is passed from one organism to another. It occurs via two mechanisms: vertical gene transfer and horizontal gene transfer. Vertical gene transfer occurs when genetic information is transferred from one generation to the next, which happens much more frequently than horizontal gene transfer. Both sexual and asexual reproduction are forms of vertical gene transfer, where one or more organisms pass some or all of their genome onto their progeny.
Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...

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    We introduce two new metrics, fast optimal transport-based conditional entropy (F-OTCE) and joint correspondence OTCE (JC-OTCE), for efficient transfer learning. These metrics improve model generalizability and reduce computation time without needing auxiliary tasks.

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    Area of Science:

    • Machine Learning
    • Artificial Intelligence
    • Computer Science

    Background:

    • Transfer learning aims to leverage knowledge from source tasks to improve performance on target tasks.
    • Evaluating the effectiveness of transfer learning, especially across different domains and tasks, remains a challenge.
    • Existing methods often require computationally expensive auxiliary tasks for transferability assessment.

    Purpose of the Study:

    • To propose novel, auxiliary-free transferability metrics for cross-domain and cross-task transfer learning.
    • To develop metrics that efficiently estimate the benefit of a source model for a target task.
    • To learn more generalizable representations for improved transfer learning performance.

    Main Methods:

    • Introduced fast optimal transport-based conditional entropy (F-OTCE) using optimal transport (OT) between source and target distributions.
    • Developed joint correspondence OTCE (JC-OTCE) by incorporating label distances into the OT problem for enhanced accuracy.
    • Utilized these metrics as objective functions for model finetuning and domain generalization (DG).

    Main Results:

    • F-OTCE and JC-OTCE significantly outperform state-of-the-art auxiliary-free metrics in correlation with transfer accuracy (21.1% and 25.8% higher, respectively).
    • The proposed metrics drastically reduce computation time, from 43 minutes to under 11 seconds per task pair.
    • F-OTCE demonstrated notable accuracy gains in few-shot classification for finetuning (up to 4.41%) and DG (up to 2.34%).

    Conclusions:

    • F-OTCE and JC-OTCE offer efficient and effective solutions for evaluating and enhancing transfer learning.
    • The auxiliary-free nature of these metrics makes them highly practical for real-world applications.
    • These metrics pave the way for more generalizable representations and improved performance in cross-domain and cross-task learning scenarios.