Related Experiment Video
Updated: Jul 4, 2025

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
AABB recommends restrictive RBC transfusions for hospitalized adults and children
Errol Moras1, J Dawn Abbott1,2, Saraschandra Vallabhajosyula2
1Ichan School of Medicine at Mount Sinai-Morningside West, New York, NY, USA (E.M., J.D.A.).
Insights
The 2023 AABB guidelines offer updated recommendations for red blood cell transfusion practices. These guidelines aim to improve patient outcomes and optimize the use of blood products in clinical settings.
Area of Science:
- Hematology
- Transfusion Medicine
- Clinical Guidelines
Background:
- Red blood cell (RBC) transfusions are common but carry risks.
- Evidence-based guidelines are crucial for safe and effective transfusion practices.
- Previous guidelines require periodic updates to reflect new research.
Purpose of the Study:
- To present the 2023 AABB international guidelines for red blood cell transfusion.
- To provide evidence-based recommendations for clinicians.
- To promote optimal use of RBC transfusions.
Main Methods:
- Systematic review of recent literature.
- Development of consensus-based recommendations by an expert panel.
- Grading of recommendations based on evidence quality.
Main Results:
- Updated guidance on transfusion triggers.
- Recommendations for specific patient populations (e.g., critical care, cardiology).
- Emphasis on patient blood management strategies.
Conclusions:
- The 2023 AABB guidelines provide a comprehensive update on RBC transfusion.
- Adherence to these guidelines can enhance patient safety and outcomes.
- Continuous evaluation of transfusion practices is essential.
Source Citation:
Carson JL, Stanworth SJ, Guyatt G, et al. Red blood cell transfusion: 2023 AABB international guidelines. JAMA. 2023;330:1892-1902. 37824153.
More Related Videos
Related Concept Videos
Blood Transfusion
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Blood Transfusion and Agglutination
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
The ABO Blood Group
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
Rh Blood Group
Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
Disorders of Erythrocytes
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...

