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Advancing Point-of-Care Applications with Droplet Microfluidics: From Single-Cell to Multicellular Analysis.
Christina Sharkey1,2, Rachel White1, Michael Finocchiaro1
1Department of Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts, USA;
Annual Review of Biomedical Engineering
|February 5, 2024
Summary
Microfluidic technologies offer advanced tools for cancer research, enabling detailed study of cancer-immune cell interactions and immunotherapy effectiveness. These methods provide insights into tumor biology and immune responses for potential point-of-care applications.
Area of Science:
- Biomedical Engineering
- Cancer Biology
- Immunology
Background:
- Microfluidics technology has advanced the study of cancer biology and immunology.
- Controlled microenvironments and single-cell analysis are crucial for understanding tumor-immune interactions.
Purpose of the Study:
- To discuss cutting-edge microfluidic technologies for cancer-immune cell interaction research.
- To assess the effectiveness of immunotherapies using microfluidic models.
- To explore applications in immunotherapy screening and point-of-care approaches.
Main Methods:
- Utilizing single-cell and multicellular microfluidic devices.
- Developing and applying 3D spheroid and single-cell microfluidic models.
- High-throughput screening and monitoring of cellular interactions.
Main Results:
- Microfluidics significantly advances understanding of tumor biology and immune responses.
- Various microfluidic models offer advantages and limitations for cancer research.
- These technologies facilitate immunotherapy screening and development.
Conclusions:
- Microfluidics provides powerful tools for investigating cancer-immune dynamics.
- 3D spheroid and single-cell models are valuable for immunotherapy assessment.
- Future applications may include point-of-care diagnostics and treatment monitoring.
