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Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Summary And Update On The Management Of Differentiated Thyroid Cancer In 2023

Summary and update on the management of differentiated thyroid cancer in 2023

Perrine Raymond1, Marc Klein1, Françoise Borson-Chazot2

  • 1Service d'endocrinologie, CHRU de Brabois, rue du Morvan, Vandœuvre-lès-Nancy, France.

Annales D'Endocrinologie
|February 5, 2024

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Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

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Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy
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Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma
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View abstract on PubMed

Summary
This summary is machine-generated.

Differentiated thyroid cancer incidence has risen due to better detection. Advances in precision oncology offer personalized treatments, improving survival for aggressive and advanced thyroid cancers.

Area of Science:

  • Endocrinology
  • Oncology
  • Precision Medicine

Background:

  • Increased incidence of differentiated thyroid cancer (DTC) over 30 years, primarily due to enhanced detection methods.
  • Significant improvements in survival rates for metastatic DTC, linked to recent therapeutic advancements.
  • Current DTC management exemplifies precision oncology, with tailored, risk-stratified treatment approaches.

Purpose of the Study:

  • To provide a comprehensive overview of current treatment strategies for differentiated thyroid cancer in 2023.
  • To highlight the shift towards personalized and risk-adapted therapeutic decisions in DTC management.
  • To discuss the evolving role of targeted therapies in advanced and radioiodine-refractory DTC.

Main Methods:

  • Review of recent literature and clinical guidelines on differentiated thyroid cancer treatment.
Keywords:
Differentiated thyroid cancerLobo-isthmectomy in low-risk cancersPapillary microcarcinoma surveillanceRadioiodine treatment and risk of recurrence

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  • Analysis of therapeutic de-escalation in low-risk DTC and targeted treatment in advanced DTC.
  • Focus on the practical implications for endocrinologists in patient monitoring and support during treatment.

    • Main Results:

    • Therapeutic de-escalation is employed for low-risk DTC, optimizing patient care.
    • Targeted treatments are crucial for managing radioiodine-refractory and advanced DTC cases.
    • Endocrinologists play a key role in supporting and monitoring patients throughout their treatment journey.

    Conclusions:

    • Differentiated thyroid cancer management is increasingly personalized and risk-adapted.
    • Targeted therapies represent a significant advancement in treating aggressive and advanced DTC.
    • Endocrinologists are integral to the multidisciplinary care of DTC patients, particularly in monitoring treatment effects.
    Wide range of therapies for advanced cancers