Epileptogenic effect of intracortically applied kainic acid in cats

The effect of two doses (5 micrograms/microliters) of kainic acid (KA) injected intracortically into the posterior lateral gyrus of cats was investigated. KA in a dose of 5 micrograms/microliters provoked cortical epileptogenic focus 8-12 min after its application, developing later into a focal seizure. Administration of 10 micrograms/microliters KA resulted after 15-20 sec in paroxysmal discharges of spikes and sharp-slow waves at the site of the application, which propagated ipsilaterally. Thereafter the paroxysmal activity spread contralaterally, became generalized and developed into an epileptic state. The effect of KA was considered to be a dose-dependent one. N-Aminomethylpiperazine-3, 3-diethyl-2, 4-pyridinedione (DKMP) in a dose of 100 mg/kg injected i.v. on the background of developed epileptic state exerted a rapid inhibitory effect of 60-100 min duration on the paroxysmal activity. employed as a model of secondary generalized focal epilepsy.