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Updated: Jul 4, 2025

High-Throughput Screening of Microbial Isolates with Impact on Caenorhabditis elegans Health
Published on: April 28, 2022
Gut microb-aging and its relevance to frailty aging
Guillaume Le Cosquer1, Nathalie Vergnolle2, Jean-Paul Motta3
1Institute of Digestive Health Research, IRSD, Toulouse University, INSERM U1220, INRAe, ENVT, UPS, 31300 Toulouse, France; Department of Gastroenterology and Pancreatology, Toulouse University Hospital, Toulouse Paul Sabatier University, 31059 Toulouse, France.
Abstract:
This review explores 'microb-aging' in the gut and its potential link to frailty aging. We explore this connection through alterations in microbiota's taxonomy and metabolism, as well as with concepts of ecological resilience, pathobionts emergence, and biogeography. We examine microb-aging in interconnected body organs, emphasizing the bidirectional relationship with 'inflammaging'. Finally, we discuss how targeting microb-aging could improve screening, diagnostic, and therapeutic approaches in geriatrics.
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