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Emerging roles of circular RNAs in regulating the hallmarks of thyroid cancer

Tianjiao Zhou1,2,3, Zheng Li4, Yumeng Jiang1,2,3

  • 1Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China.

Cancer Gene Therapy
|February 5, 2024
PubMed

Insights

Circular RNAs significantly impact thyroid cancer development. This review details their roles in eight cancer hallmarks, offering insights for future research and treatments.

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Oncology

Background:

  • Thyroid cancer incidence is rising, with aggressive forms posing significant mortality risks.
  • Mechanisms driving thyroid cancer progression, such as recurrence and metastasis, are not fully understood.
  • Circular RNAs (circRNAs) are emerging as key regulators in various cancers.

Purpose of the Study:

  • To review and summarize identified circular RNAs in thyroid cancers over the last decade.
  • To correlate circRNAs with the established hallmarks of cancer in thyroid malignancies.
  • To identify knowledge gaps regarding circRNA involvement in thyroid cancer biology.

Main Methods:

  • Literature review of studies on circular RNAs in thyroid cancer published in the past 10 years.
  • Categorization of identified circRNAs based on the 14 hallmarks of cancer.
  • Analysis of the reported regulatory roles of circRNAs in thyroid cancer progression.

Main Results:

  • Eight of the 14 hallmarks of cancer are demonstrably regulated by circular RNAs in thyroid cancer.
  • Specific circular RNAs have been linked to key malignant features like dedifferentiation and radioiodine resistance.
  • Six hallmarks of cancer show no reported correlation with circular RNAs in thyroid cancer to date.

Conclusions:

  • Circular RNAs play a substantial role in multiple facets of thyroid cancer progression.
  • Further research into circRNA mechanisms is crucial for understanding thyroid cancer and developing novel therapies.
  • This review highlights the importance of circRNAs in endocrine oncology and potential therapeutic targets.

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