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Exploring The Therapeutic Potential Of Ginkgo Biloba Polyphenols In Targeting Biomarkers Of Colorectal Cancer: An In-silico Evaluation.

Home
Research Domains
Biomedical And Clinical Sciences
Oncology And Carcinogenesis
Predictive And Prognostic Markers
Exploring The Therapeutic Potential Of Ginkgo Biloba Polyphenols In Targeting Biomarkers Of Colorectal Cancer: An In-silico Evaluation.

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Exploring the Therapeutic Potential of Ginkgo biloba Polyphenols in Targeting Biomarkers of Colorectal Cancer: An In-silico Evaluation.

Sarra Hamdani^1,2, Hocine Allali^1,2, Salim Bouchentouf^2,3

¹Department of Chemistry, Faculty of Sciences, Abou Bekr Belkaïd University, P.O. Box 119, Tlemcen 13000, Algeria.

Current Drug Discovery Technologies

|February 6, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Ginkgo biloba compounds show promise as natural colorectal cancer treatments. Molecular docking revealed strong binding to key CRC biomarkers, suggesting potential for new therapies with fewer side effects.

Keywords:

Colorectal cancer Ginkgo biloba colorectal biomarkers docking scoring

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Area of Science:

Phytochemistry
Computational Biology
Oncology

Background:

Colorectal cancer (CRC) is a leading cause of cancer mortality globally.
There is a critical need for novel CRC therapies with improved safety profiles.
Natural products, such as Ginkgo biloba, offer potential for discovering new anticancer agents.

Purpose of the Study:

To investigate the binding affinity of Ginkgo biloba-derived molecules to CRC biomarkers using molecular docking.
To identify potential natural inhibitors for colorectal cancer treatment.
To evaluate the efficacy of G. biloba compounds against key CRC molecular targets.

Main Methods:

Selection of 152 polyphenolic compounds from G. biloba.
Performance of molecular docking simulations to assess ligand-biomarker interactions.

targeted genes.

Analysis of docking scores to identify compounds with high binding affinity to CRC-related genes.

Main Results:

Docking simulations identified strong binding affinities between G. biloba polyphenols and CRC biomarkers.
Flavonol glycoside structures, particularly complex ones, demonstrated significant interactions.
Promising docking scores indicated substantial inhibitory potential of selected compounds.

Conclusions:

Ginkgo biloba-derived molecules show potential as natural anticancer agents for CRC.
Identified compounds exhibit strong interactions with critical CRC biomarkers, suggesting therapeutic utility.
Further in vitro and in vivo studies are warranted to validate these findings for novel CRC therapy development.