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[Establishment and verification of a prognostic nomogram for survival of tongue squamous cell carcinoma patients who underwent cervical dissection]

  • 0Department of Clinical Laboratory, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing 100081, China.
Beijing Da Xue Xue Bao. Yi Xue Ban = Journal of Peking University. Health Sciences +

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February 6, 2024

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February 6, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Prognostic nutritional index (PNI), N category, depth of invasion, and tumor size are key predictors for tongue squamous cell carcinoma (TSCC) survival. A developed nomogram accurately forecasts overall survival (OS) and disease-specific survival (DSS) in TSCC patients.

Area Of Science

  • Oncology
  • Biomarkers
  • Surgical Pathology

Context

  • Tongue squamous cell carcinoma (TSCC) prognosis is influenced by various factors.
  • Accurate prediction of survival is crucial for treatment planning in TSCC patients undergoing cervical dissection.

Purpose

  • To evaluate the prognostic significance of inflammatory biomarkers, prognostic nutritional index (PNI), and clinicopathological characteristics in TSCC patients.
  • To develop and validate a predictive nomogram for overall survival (OS) and disease-specific survival (DSS).

Summary

  • A retrospective study of 297 TSCC patients identified pre-treatment PNI, clinical N category, depth of invasion (DOI), and tumor size as independent prognostic factors.
  • Multivariate analysis confirmed these factors' association with OS and DSS. A nomogram incorporating these variables demonstrated robust predictive accuracy, validated internally and externally.
  • The nomogram showed good discriminative ability and calibration for predicting 1-, 3-, and 5-year survival outcomes.

Impact

  • The findings highlight the potential of PNI, N category, DOI, and tumor size as predictive markers for TSCC.
  • The validated prognostic nomogram serves as an effective tool for survival prediction and guiding treatment strategies in TSCC patients.
  • This research aids in personalized treatment approaches to improve patient outcomes in TSCC.

Keywords: