Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Standard Methods for Quality Control in Cell-Based Medicinal Products and their Validation for Clinical Applications.

Advanced biomedical research·2026
Same author

Determinants of MSC immunophenotypic plasticity: From canonical priming to emerging strategies for cancer and inflammatory therapies.

Biochimica et biophysica acta. Reviews on cancer·2026
Same author

Translating Human Prototype Liver Implant Technology from Academia to Industry for Third-Party Transplant and In Vivo Validation.

Cells·2026
Same author

Impact of stem cell therapy on brain metabolic profile in cerebral palsy assessed by magnetic resonance spectroscopy in a randomized clinical trial.

Scientific reports·2026
Same author

Targeting PCSK9, APOB, and CETP at the Transcriptome Level by hsa-miR-30b-3p Reduces LDL-Associated Protein in Huh-7 Cells.

Molecular biology reports·2026
Same author

Mechanical signature of cancer cells: From cytoskeletal alterations to cell rheology.

Progress in biophysics and molecular biology·2026

Related Experiment Video

Updated: Jul 4, 2025

Decellularization and Recellularization of Whole Livers
09:24

Decellularization and Recellularization of Whole Livers

Published on: February 4, 2011

22.0K

Bioengineering vascularized liver tissue for biomedical research and application.

Parsa Davoodi1, Niloofar Rezaei1, Moustapha Hassan2

  • 1Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.

Scandinavian Journal of Gastroenterology
|February 6, 2024
PubMed
Summary

Liver tissue bioengineering offers a promising alternative to transplantation for end-stage liver disease. This approach aims to create implantable, vascularized liver tissues for therapeutic use and advanced in vitro disease modeling.

Keywords:
3D bio-printingLiver tissue bioengineeringregenerative medicinetissue engineeringvascularization strategies

More Related Videos

Engineered Vascularized Muscle Flap
08:18

Engineered Vascularized Muscle Flap

Published on: January 11, 2016

8.3K
Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber
09:55

Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber

Published on: May 30, 2016

8.9K

Related Experiment Videos

Last Updated: Jul 4, 2025

Decellularization and Recellularization of Whole Livers
09:24

Decellularization and Recellularization of Whole Livers

Published on: February 4, 2011

22.0K
Engineered Vascularized Muscle Flap
08:18

Engineered Vascularized Muscle Flap

Published on: January 11, 2016

8.3K
Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber
09:55

Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber

Published on: May 30, 2016

8.9K

Area of Science:

  • Regenerative Medicine
  • Tissue Engineering
  • Hepatology

Background:

  • Liver damage can lead to progressive disease and organ failure, with transplantation being the only current long-term treatment.
  • Orthotopic liver transplantation faces challenges such as organ scarcity and the need for lifelong immunosuppression.
  • Novel therapeutic strategies are crucial for managing end-stage liver disease.

Purpose of the Study:

  • To review recent advancements in liver tissue bioengineering.
  • To explore the potential of engineered liver tissue for therapeutic applications and in vitro modeling.
  • To highlight key technologies and approaches in the field.

Main Methods:

  • Review of microfluidic-based systems for liver tissue engineering.
  • Analysis of bio-printing techniques for vascularized liver constructs.
  • Evaluation of liver spheroids and organoid models.
  • Assessment of in vivo angiogenesis induction strategies.

Main Results:

  • Significant progress has been made in engineering vascularized liver tissue.
  • Various bioengineering approaches, including microfluidics, bio-printing, spheroids, and organoids, show promise.
  • In vivo angiogenesis induction is a key factor for successful tissue integration.

Conclusions:

  • Liver tissue bioengineering presents a viable alternative to transplantation for liver disease.
  • Engineered liver tissues can serve as advanced models for studying human health, disease, and aging.
  • Continued research in bioengineering holds potential for transformative therapies and research tools.