Related Experiment Video
Updated: Jul 23, 2026
08:54
Human In-Vivo Bioassay for the Tissue-Specific Measurement of Nociceptive and Inflammatory Mediators
Published on: December 1, 2008
10.3K
NEJM Evidence - A New Journal in the NEJM Group Family
NEJM Evidence
|February 6, 2024
Summary
NEJM Group is launching NEJM Evidence, a new monthly online journal in January 2022. It will publish peer-reviewed original research across the full spectrum of clinical investigation.
Area of Science:
- Clinical Investigation
- Medical Research
- Evidence-Based Medicine
Background:
- The NEJM Group is expanding its portfolio with a new publication.
- NEJM Evidence will commence publication in January 2022.
Discussion:
- The journal aims to bridge the gap between research ideas and clinical application.
- It will cover the complete range of clinical investigation.
Key Insights:
- Focus on translating research findings into practical medical realities.
- Commitment to rigorous peer review for all published content.
Outlook:
- Establishment of a new platform for disseminating high-impact clinical research.
- Monthly publication schedule to ensure timely dissemination of findings.
Related Concept Videos
01:35Pedigree Analysis
Overview
01:33Pleiotropy
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
00:46Motor Units
A motor unit consists of two main components: a single efferent motor neuron (i.e., a neuron that carries impulses away from the central nervous system) and all of the muscle fibers it innervates. The motor neuron may innervate multiple muscle fibers, which are single cells, but only one motor neuron innervates a single muscle fiber.
01:29Non-nuclear Inheritance
Most DNA resides in the nucleus of a cell. However, some organelles in the cell cytoplasm—such as chloroplasts and mitochondria—also have their own DNA. These organelles replicate their DNA independently of the nuclear DNA of the cell in which they reside. Non-nuclear inheritance describes the inheritance of genes from structures other than the nucleus.
01:29Nondisjunction
During meiosis, chromosomes occasionally separate improperly. This occurs due to failure of homologous chromosome separation during meiosis I or failed sister chromatid separation during meiosis II. In some species, notably plants, nondisjunction can result in an organism with an entire additional set of chromosomes, which is called polyploidy. In humans, nondisjunction can occur during male or female gametogenesis and the resulting gametes possess one too many or one too few chromosomes.
02:59Animal Mitochondrial Genetics
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...