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Behind the Scenes of TOPCAT - Bending to Inform
Marc A Pfeffer1, Brian Claggett1
1Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston.
Abstract:
Behind the Scenes of TOPCAT - Bending to InformWhen investigators in a 2013 RCT received their unblinded results, the data forced them to make a difficult decision - do they stay within conventional guidelines for data analysis or forge a new path? This Clinical Trial Case Study tells the story of how they dealt with the data dilemma for a heart failure treatment that affects millions of people.
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