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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Circulating osteoprotegerin as a cardiac biomarker for left ventricular diastolic dysfunction in patients with

Sang Heon Suh1, Tae Ryom Oh1, Hong Sang Choi1

  • 1Department of Internal Medicine, Chonnam National University Medical School and Chonnam National University Hospital, 42 Jebongro, Gwangju, 61469, Korea.

Clinical Research in Cardiology : Official Journal of the German Cardiac Society
|February 6, 2024
PubMed

Insights

Elevated serum osteoprotegerin (OPG) levels are linked to a higher risk of left ventricular diastolic dysfunction (LVDD) in patients with chronic kidney disease (CKD). OPG may aid in diagnosing LVDD, a key feature of heart failure with preserved ejection fraction (HFpEF).

Area of Science:

  • Nephrology
  • Cardiology
  • Biomarkers

Background:

  • Heart failure with preserved ejection fraction (HFpEF) significantly contributes to mortality in chronic kidney disease (CKD) patients.
  • Diagnosing HFpEF in CKD is challenging, lacking validated specific biomarkers.
  • Left ventricular diastolic dysfunction (LVDD) serves as a surrogate for HFpEF.

Purpose of the Study:

  • To investigate the association between serum osteoprotegerin (OPG) levels and the risk of LVDD in pre-dialysis CKD patients.
  • To explore OPG as a potential diagnostic marker for LVDD in this population.

Main Methods:

  • Cross-sectional analysis of 2039 pre-dialysis CKD patients (Stages 1-5).
  • Patients were stratified into quartiles based on serum OPG levels.
  • LVDD was defined as an E/e' ratio > 14.

Main Results:

  • Higher serum OPG levels correlated with HFpEF risk factors.
  • A moderate positive correlation was observed between serum OPG and E/e' (R=0.351, P<0.001).
  • Increased LVDD risk was noted in higher OPG quartiles (Q3: aOR 2.576; Q4: aOR 3.536) compared to the lowest (Q1).

Conclusions:

  • Elevated serum OPG levels are significantly associated with LVDD risk in pre-dialysis CKD.
  • Serum OPG measurement may assist in diagnosing LVDD, an echocardiographic marker of HFpEF.
Abstract

Keywords:
BiomarkerChronic kidney diseaseLeft ventricular diastolic dysfunctionOsteoprotegerin

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